Cheap flights from Tampa to Panama City from $276

In general, April is the cheapest month to fly from Tampa to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $513. If you’re not able to fly to Panama City in April, then March is your next best option. Flight prices from Tampa to Panama City during March average around $514.

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $479. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $509. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Tampa to Panama City during this time can be as low as $453. Try not to purchase tickets in the afternoon because they tend to be around $520. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Tampa to Panama City Tocumen Intl for the best Tampa - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Tampa when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $578 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Tampa for as low as $469 on momondo.

There are 3 cabin classes available to choose from on Tampa to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 22% on your flight if you consider stops on a Tampa to Panama City flight.

As of September 2026, prices for Tampa to Panama City flights are approximately 11% more expensive when compared to flights at the same time last year.

Copa Airlines, United Airlines, and American Airlines are the most popular carriers operating from Tampa to Panama City Tocumen Intl

Copa Airlines, Avianca and American Airlines are the top three most popular airlines that fly to Panama City from Tampa according to our data. Copa Airlines is the first choice among our users, with 88% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Houston (IAH) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

Flights via Miami (MIA) offer the lowest average round-trip price of $344.

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 5h 47m.

Miami (MIA) has the shortest average layover time for this route: 2h 01m.

As of September 2026, there are 2 flights per day flying from Tampa to Panama City. The most common time of day flights depart is 3:00PM, with 73% of flights taking off in the afternoon.

As of September 2026, there are 19 flights per week flying from Tampa to Panama City. The most common day of the week flights depart is Mon, with 16% of flights taking off on this day.