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Cheap flights from South Carolina to Brussels from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Brussels departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
2:51 pm - 1:15 pm
CHS
-
BRU
16h 24m
2 stops
United Airlines Logo
12:00 pm - 6:59 pm
BRU
-
CHS
12h 59m
1 stop
$505United Airlines
Wed, Apr 22 - Tue, Apr 28
Air Canada Logo
6:30 am - 7:10 am
CHS
-
BRU
18h 40m
2 stops
Air Canada Logo
9:25 am - 8:51 am
BRU
-
CHS
29h 26m
2 stops
$506Air Canada
Wed, Apr 22 - Tue, Apr 28
Delta Logo
7:25 am - 7:40 am
CHS
-
BRU
18h 15m
1 stop
Delta Logo
9:45 am - 8:41 pm
BRU
-
CHS
16h 56m
1 stop
$508Delta
Wed, Apr 22 - Tue, Apr 28
Multiple Airlines Logo
8:00 am - 7:10 am
CHS
-
BRU
17h 10m
2 stops
Multiple Airlines Logo
9:25 am - 10:13 am
BRU
-
CHS
30h 48m
2 stops
$513Multiple Airlines
Wed, Apr 22 - Tue, Apr 28
Air Canada Logo
11:05 am - 7:50 am
CHS
-
BRU
14h 45m
1 stop
Air Canada Logo
9:25 am - 10:13 am
BRU
-
CHS
30h 48m
2 stops
$514Air Canada
Wed, Apr 22 - Tue, Apr 28
Air Canada Logo
9:30 am - 7:50 am
CLT
-
BRU
16h 20m
1 stop
Air Canada Logo
9:40 am - 2:57 pm
BRU
-
CLT
11h 17m
1 stop
$580Air Canada
Sun, Apr 19 - Tue, May 5
United Airlines Logo
10:34 am - 9:00 am
CLT
-
BRU
16h 26m
1 stop
United Airlines Logo
9:25 am - 1:21 pm
BRU
-
CLT
33h 56m
2 stops
$583United Airlines
Tue, Apr 7 - Tue, Apr 14
Multiple Airlines Logo
3:35 pm - 1:15 pm
CLT
-
BRU
15h 40m
2 stops
Multiple Airlines Logo
4:25 pm - 4:45 pm
BRU
-
CLT
30h 20m
1 stop
$584Multiple Airlines
Mon, May 4 - Mon, May 11
KLM Logo
5:07 pm - 6:40 am
CAE
-
BRU
32h 33m
1 stop
KLM Logo
9:45 am - 11:56 pm
BRU
-
CAE
20h 11m
1 stop
$636KLM
Sat, Mar 28 - Tue, Apr 21
Delta Logo
8:28 am - 7:35 am
CAE
-
BRU
42h 07m
2 stops
Delta Logo
10:00 am - 9:24 pm
BRU
-
CAE
40h 24m
2 stops
$836Delta
Sat, Mar 21 - Sat, Mar 28

Lufthansa flights from South Carolina to Brussels Bruxelles-National Airport

Our best Lufthansa deals on South Carolina to Brussels Bruxelles-National Airport flight tickets
Lufthansa
May 6
CHS6:53 pmCharleston
19h 47m
2 stops
BRU8:40 pmBrussels Bruxelles-National
May 13
BRU9:30 amBrussels Bruxelles-National
20h 29m
2 stops
CHS11:59 pmCharleston
$611
Lufthansa
May 18
CLT6:40 pmCharlotte Douglas
12h 30m
1 stop
BRU1:10 pmBrussels Bruxelles-National
May 27
BRU6:45 amBrussels Bruxelles-National
16h 00m
1 stop
CLT4:45 pmCharlotte Douglas
$633
Lufthansa
May 18
CLT6:40 pmCharlotte Douglas
19h 15m
1 stop
BRU7:55 pmBrussels Bruxelles-National
May 27
BRU10:30 amBrussels Bruxelles-National
19h 29m
2 stops
CLT11:59 pmCharlotte Douglas
$641

KLM flights from South Carolina to Brussels Bruxelles-National Airport

Our best KLM deals on South Carolina to Brussels Bruxelles-National Airport flight tickets
KLM
Mar 28
CAE5:07 pmColumbia Metropolitan
32h 33m
1 stop
BRU6:40 amBrussels Bruxelles-National
Apr 21
BRU9:45 amBrussels Bruxelles-National
20h 11m
1 stop
CAE11:56 pmColumbia Metropolitan
$636
KLM
Mar 24
CHS5:56 pmCharleston
33h 04m
1 stop
BRU8:00 amBrussels Bruxelles-National
Mar 31
BRU9:45 amBrussels Bruxelles-National
20h 10m
1 stop
CHS11:55 pmCharleston
$637
KLM
Apr 9
CHS7:58 pmCharleston
29h 42m
1 stop
BRU7:40 amBrussels Bruxelles-National
Apr 14
BRU9:45 amBrussels Bruxelles-National
18h 10m
1 stop
CHS9:55 pmCharleston
$655

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from South Carolina to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Wed 4/22

2:51 pm-1:15 pm

2 stops16h 24m

Brussels Bruxelles-National

Tue 4/28

12:00 pm-6:59 pm

1 stop12h 59m

$505

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Wed 4/22

6:30 am-7:10 am

2 stops18h 40m

Brussels Bruxelles-National

Tue 4/28

9:25 am-8:51 am

2 stops29h 26m

$506

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Wed 4/22

7:25 am-7:40 am

1 stop18h 15m

Brussels Bruxelles-National

Tue 4/28

9:45 am-8:41 pm

1 stop16h 56m

$508

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Wed 4/22

8:00 am-7:10 am

2 stops17h 10m

Brussels Bruxelles-National

Tue 4/28

9:25 am-10:13 am

2 stops30h 48m

$513

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Wed 4/22

11:05 am-7:50 am

1 stop14h 45m

Brussels Bruxelles-National

Tue 4/28

9:25 am-10:13 am

2 stops30h 48m

$514

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Sun 4/19

9:30 am-7:50 am

1 stop16h 20m

Brussels Bruxelles-National

Tue 5/5

9:40 am-2:57 pm

1 stop11h 17m

$580

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Tue 4/7

10:34 am-9:00 am

1 stop16h 26m

Brussels Bruxelles-National

Tue 4/14

9:25 am-1:21 pm

2 stops33h 56m

$583

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Mon 5/4

3:35 pm-1:15 pm

2 stops15h 40m

Brussels Bruxelles-National

Mon 5/11

4:25 pm-4:45 pm

1 stop30h 20m

$584

ColumbiaBrussels

CAE - BRU

CAEBRU

Columbia Metropolitan

Sat 3/28

5:07 pm-6:40 am

1 stop32h 33m

Brussels Bruxelles-National

Tue 4/21

9:45 am-11:56 pm

1 stop20h 11m

$636

ColumbiaBrussels

CAE - BRU

CAEBRU

Columbia Metropolitan

Sat 3/21

8:28 am-7:35 am

2 stops42h 07m

Brussels Bruxelles-National

Sat 3/28

10:00 am-9:24 pm

2 stops40h 24m

$836

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from South Carolina to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Brussels Bruxelles-National Airport flights?

You could potentially save up to 61% on your flight if you consider stops on a South Carolina to Brussels Bruxelles-National Airport flight.

Cheap South Carolina to Brussels Bruxelles-National Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Brussels Bruxelles-National Airport

Fastest flight time

10h 28m

Direct flights

None
The fastest flight from South Carolina to Brussels Bruxelles-National Airport takes 10h 28m
There are no direct flights from South Carolina to Brussels Bruxelles-National Airport. There are no popular flight routes from South Carolina to Brussels Bruxelles-National Airport.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Brussels Bruxelles-National Airport?

    Prices for flights from South Carolina to Brussels Bruxelles-National Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from South Carolina to Brussels Bruxelles-National Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The necessary travel and health documents for your Brussels Bruxelles-National Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from South Carolina to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $591Free CancellationRating
7.4
9,342 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Ghent
Bruges
Leuven
Charleroi
Zaventem
Hasselt
Namur
Dinant
Genk
Waterloo
Mons
Durbuy
Spa
Aalst
Knokke-Heist
Mechelen
Francorchamps
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Brussels?

Finding the right flight to Brussels from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Brussels quick and easy, saving you time and money.

Can I find flights from South Carolina to Brussels with flexible booking policies on momondo?

All flight searches from South Carolina to Brussels on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from South Carolina to Brussels?

momondo provides multiple filters to help you find the best flight to Brussels from South Carolina. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Carolina to Brussels right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Brussels flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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