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Cheap flights from Santo Domingo to Panama City from $228

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Panama City departing on 11/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santo Domingo to Panama City

Cheap round-trip flights

Avianca Logo
11:45 am - 12:10 amSDQ-PTY
13h 25m1 stop
Avianca Logo
11:00 am - 5:15 pmPTY-SDQ
5h 15m1 stop
$458Avianca
Find Deal
dt., ag. 19 - dv., ag. 22
Avianca Logo
11:45 am - 4:30 pmSDQ-PTY
5h 45m1 stop
Avianca Logo
3:20 am - 10:50 amPTY-SDQ
6h 30m1 stop
$469Avianca
Find Deal
dj., ag. 14 - dg., ag. 17
Avianca Logo
6:15 pm - 12:20 amSDQ-PTY
7h 05m1 stop
Avianca Logo
9:55 pm - 10:55 amPTY-SDQ
12h 00m1 stop
$474Avianca
Find Deal
dv., des. 26 - dl., gen. 5
Avianca Logo
11:45 am - 12:10 amSDQ-PTY
13h 25m1 stop
Avianca Logo
3:20 am - 10:50 amPTY-SDQ
6h 30m1 stop
$498Avianca
Find Deal
dj., set. 11 - dg., set. 14
Avianca Logo
6:10 pm - 12:10 amSDQ-PTY
7h 00m1 stop
Avianca Logo
3:20 am - 5:15 pmPTY-SDQ
12h 55m1 stop
$499Avianca
Find Deal
dj., set. 25 - ds., set. 27
Copa Airlines Logo
8:59 am - 10:30 amSDQ-PTY
2h 31mnonstop
Copa Airlines Logo
9:37 am - 1:09 pmPTY-SDQ
2h 32mnonstop
$522Copa Airlines
Find Deal
dj., set. 25 - dg., set. 28
Logo
3:35 pm - 12:35 pmSDQ-PTY
22h 00m2 stops
Logo
9:55 am - 5:15 pmPTY-SDQ
6h 20m1 stop
$528
Find Deal
dj., oct.. 16 - ds., oct.. 18
Copa Airlines Logo
6:17 pm - 7:50 pmSDQ-PTY
2h 33mnonstop
Copa Airlines Logo
11:13 pm - 2:43 amPTY-SDQ
2h 30mnonstop
$594Copa Airlines
Find Deal
dj., ag. 14 - dl., ag. 18
Copa Airlines Logo
11:55 am - 1:32 pmSDQ-PTY
2h 37mnonstop
Copa Airlines Logo
7:28 am - 10:50 amPTY-SDQ
2h 22mnonstop
$654Copa Airlines
Find Deal
dv., des. 19 - dg., febr. 22
Copa Airlines Logo
11:54 am - 1:29 pmSDQ-PTY
2h 35mnonstop
Copa Airlines Logo
7:26 am - 10:58 amPTY-SDQ
2h 32mnonstop
$657Copa Airlines
Find Deal
dt., ag. 12 - ds., ag. 23

Copa Airlines flights from Santo Domingo to Panama City

Our best Copa Airlines deals on Santo Domingo to Panama City flight tickets
Copa Airlines
Sep 25
SDQ8:59 amSanto Domingo Las Americas
2h 31m
PTY10:30 amPanama City Tocumen Intl
Sep 28
PTY9:37 amPanama City Tocumen Intl
2h 32m
SDQ1:09 pmSanto Domingo Las Americas
$522
Find similar
Copa Airlines
Aug 14
SDQ6:17 pmSanto Domingo Las Americas
2h 33m
PTY7:50 pmPanama City Tocumen Intl
Aug 18
PTY11:13 pmPanama City Tocumen Intl
2h 30m
SDQ2:43 amSanto Domingo Las Americas
$594
Find similar
Copa Airlines
Dec 19
SDQ11:55 amSanto Domingo Las Americas
2h 37m
PTY1:32 pmPanama City Tocumen Intl
Feb 22
PTY7:28 amPanama City Tocumen Intl
2h 22m
SDQ10:50 amSanto Domingo Las Americas
$654
Find similar

Avianca flights from Santo Domingo to Panama City

Our best Avianca deals on Santo Domingo to Panama City flight tickets
Avianca
Aug 9
SDQ11:45 amSanto Domingo Las Americas
13h 25m
1 stop
PTY12:10 amPanama City Tocumen Intl
Aug 11
PTY10:05 pmPanama City Tocumen Intl
11h 45m
1 stop
SDQ10:50 amSanto Domingo Las Americas
$458
Find similar
Avianca
Aug 14
SDQ11:45 amSanto Domingo Las Americas
5h 45m
1 stop
PTY4:30 pmPanama City Tocumen Intl
Aug 17
PTY3:20 amPanama City Tocumen Intl
6h 30m
1 stop
SDQ10:50 amSanto Domingo Las Americas
$469
Find similar
Avianca
Aug 9
SDQ11:45 amSanto Domingo Las Americas
13h 25m
1 stop
PTY12:10 amPanama City Tocumen Intl
Aug 10
PTY3:20 amPanama City Tocumen Intl
6h 30m
1 stop
SDQ10:50 amSanto Domingo Las Americas
$474
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agost 2, 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dt. 8/19

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

dv. 8/22

11:00 am-5:15 pm

1 stop5h 15m

$458

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 8/14

11:45 am-4:30 pm

1 stop5h 45m

Panama City Tocumen Intl

dg. 8/17

3:20 am-10:50 am

1 stop6h 30m

$469

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dv. 12/26

6:15 pm-12:20 am

1 stop7h 05m

Panama City Tocumen Intl

dl. 1/5

9:55 pm-10:55 am

1 stop12h 00m

$474

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 9/11

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

dg. 9/14

3:20 am-10:50 am

1 stop6h 30m

$498

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 9/25

6:10 pm-12:10 am

1 stop7h 00m

Panama City Tocumen Intl

ds. 9/27

3:20 am-5:15 pm

1 stop12h 55m

$499

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 9/25

8:59 am-10:30 am

Nonstop2h 31m

Panama City Tocumen Intl

dg. 9/28

9:37 am-1:09 pm

Nonstop2h 32m

$522

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 10/16

3:35 pm-12:35 pm

2 stops22h 00m

Panama City Tocumen Intl

ds. 10/18

9:55 am-5:15 pm

1 stop6h 20m

$528

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dj. 8/14

6:17 pm-7:50 pm

Nonstop2h 33m

Panama City Tocumen Intl

dl. 8/18

11:13 pm-2:43 am

Nonstop2h 30m

$594

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dv. 12/19

11:55 am-1:32 pm

Nonstop2h 37m

Panama City Tocumen Intl

dg. 2/22

7:28 am-10:50 am

Nonstop2h 22m

$654

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

dt. 8/12

11:54 am-1:29 pm

Nonstop2h 35m

Panama City Tocumen Intl

ds. 8/23

7:26 am-10:58 am

Nonstop2h 32m

$657

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Santo Domingo to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from Santo Domingo to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $420. If you’re not able to fly to Panama City in October, then September is your next best option. Flight prices from Santo Domingo to Panama City during September average around $421.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $359. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $488. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Santo Domingo to Panama City during this time can be as low as $386. Try not to purchase tickets at noon because they tend to be around $434. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santo Domingo Las Americas to Panama City Tocumen Intl flight route?

Fly from Santo Domingo Las Americas to Panama City Tocumen Intl for the best Santo Domingo Las Americas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $462 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santo Domingo for as low as $407 on momondo.

What cabin class options are available on Santo Domingo Las Americas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Santo Domingo Las Americas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Santo Domingo to Panama City flight prices changed over time?

As of August 2025, prices for Santo Domingo to Panama City flights are approximately 59% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Panama City (SDQ to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Panama City

Best Price Found

$228

Fastest flight time

2h 31m

Direct flights

Tue, Wed, Thu, Fri, Sat and Sun

Airports in Panama City

1 airport
The best one-way flight to Panama City from Santo Domingo in the past 72 hours is $228. The best round-trip flight deal from Santo Domingo to Panama City found on momondo in the last 72 hours is $458.
The fastest flight from Santo Domingo to Panama City takes 2h 31m
Direct flights go from Santo Domingo to Panama City on Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Santo Domingo Las Americas to Panama City Tocumen Intl by plane?

    The straight-line distance from Santo Domingo Las Americas to Panama City Tocumen Intl is 918.3 mi. Flights usually cover this in 2h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santo Domingo to Panama City?

  • What is the most popular airline from Santo Domingo to Panama City?

Best airlines flying from Santo Domingo to Panama City

Compare and see reviews for airlines that fly from Santo Domingo to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $281Free CancellationRating
6.7
2,388 reviews
Search Avianca flights
Copa AirlinesPriceFrom $418Free CancellationRating
7.5
1,493 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Santo Domingo to Panama City

    Copa Airlines flies from Santo Domingo to Panama City around 25 times per week, with 1,493 momondo users rating the airline 7.5/10. The cheapest Copa Airlines deal from Santo Domingo to Panama City in the last 72 hours was $418 (round-trip), much lower than the average airfare cost of $495 for Copa Airlines flights on this route.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santo Domingo to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santo Domingo to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Santo Domingo with this policy.

How can momondo help me find flights from Santo Domingo to Panama City?

Once all potential Santo Domingo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santo Domingo to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santo Domingo to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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dj. 8/7
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