Cheap flights from Santo Domingo to Panama City from $250

In general, May is the cheapest month to fly from Santo Domingo to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $429. If you’re not able to fly to Panama City in May, then August is your next best option. Flight prices from Santo Domingo to Panama City during August average around $473.

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $395. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $514. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Santo Domingo to Panama City during this time can be as low as $412. Try not to purchase tickets in the evening because they tend to be around $525. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Santo Domingo Las Americas to Panama City Tocumen Intl for the best Santo Domingo Las Americas - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $507 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santo Domingo for as low as $439 on momondo.

There are 3 cabin classes available to choose from on Santo Domingo Las Americas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 58% on your flight if you consider stops on a Santo Domingo to Panama City flight.

As of March 2026, prices for Santo Domingo to Panama City flights are approximately 64% more expensive when compared to flights at the same time last year.

Historically, on average around 5% of flights between Santo Domingo and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 133 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 5% of their flights experiencing any sort of delay.

As of March 2026, 8 flights take off from Santo Domingo and land in Panama City each day. The most common flight departure time for this route is 2:00PM, with 44% of daily flights taking off in the afternoon.

62 flights are operational weekly from Santo Domingo to Panama City as of March 2026. The most popular departure day for this route is Tue, with 16% of flights per week taking off on this day.