Cheap flights from Santo Domingo to Panama City from $218

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Panama City departing on 3/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
12:20 pm - 4:55 pm
SDQ
-
PTY
5h 35m
1 stop
Avianca Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m
1 stop
$454Avianca
Thu, Feb 12 - Sun, Feb 15
Avianca Logo
12:20 pm - 1:00 am
SDQ
-
PTY
13h 40m
1 stop
Avianca Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m
1 stop
$455Avianca
Sat, Feb 21 - Fri, Feb 27
Avianca Logo
5:45 pm - 1:00 am
SDQ
-
PTY
8h 15m
1 stop
Avianca Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m
1 stop
$477Avianca
Sat, Feb 7 - Sat, Dec 19
Avianca Logo
12:20 pm - 1:00 am
SDQ
-
PTY
13h 40m
1 stop
Avianca Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m
1 stop
$483Avianca
Thu, Feb 12 - Mon, Feb 16
Avianca Logo
11:45 am - 12:10 am
SDQ
-
PTY
13h 25m
1 stop
Avianca Logo
10:05 pm - 10:50 am
PTY
-
SDQ
11h 45m
1 stop
$501Avianca
Tue, Apr 21 - Sun, Apr 26
Avianca Logo
5:45 pm - 12:40 am
SDQ
-
PTY
7h 55m
1 stop
Avianca Logo
5:50 pm - 11:25 am
PTY
-
SDQ
16h 35m
1 stop
$507Avianca
Wed, Mar 4 - Fri, Mar 13
Multiple Airlines Logo
6:04 am - 4:55 pm
SDQ
-
PTY
11h 51m
2 stops
Multiple Airlines Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m
1 stop
$532Multiple Airlines
Thu, Mar 12 - Thu, Mar 19
Multiple Airlines Logo
12:41 pm - 12:45 am
SDQ
-
PTY
13h 04m
2 stops
Multiple Airlines Logo
11:05 am - 5:15 pm
PTY
-
SDQ
5h 10m
1 stop
$543Multiple Airlines
Mon, Mar 30 - Fri, Apr 3
Multiple Airlines Logo
5:45 pm - 8:50 am
SDQ
-
PTY
16h 05m
1 stop
Multiple Airlines Logo
5:50 pm - 3:05 pm
PTY
-
SDQ
20h 15m
2 stops
$545Multiple Airlines
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
3:32 pm - 2:00 pm
SDQ
-
PTY
23h 28m
3 stops
Multiple Airlines Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m
1 stop
$546Multiple Airlines
Thu, Feb 26 - Sat, Feb 28

Avianca flights from Santo Domingo to Panama City

Our best Avianca deals on Santo Domingo to Panama City flight tickets
Avianca
Feb 12
SDQ12:20 pmSanto Domingo Las Americas
5h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
Feb 15
PTY9:45 amPanama City Tocumen Intl
6h 05m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
$454
Avianca
Feb 21
SDQ12:20 pmSanto Domingo Las Americas
13h 40m
1 stop
PTY1:00 amPanama City Tocumen Intl
Feb 27
PTY2:55 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
$455
Avianca
Feb 7
SDQ5:45 pmSanto Domingo Las Americas
8h 15m
1 stop
PTY1:00 amPanama City Tocumen Intl
Dec 19
PTY2:55 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
$477

Copa Airlines flights from Santo Domingo to Panama City

Our best Copa Airlines deals on Santo Domingo to Panama City flight tickets
Copa Airlines
Mar 2
SDQ11:56 amSanto Domingo Las Americas
2h 36m
PTY1:32 pmPanama City Tocumen Intl
Mar 5
PTY12:44 pmPanama City Tocumen Intl
2h 30m
SDQ4:14 pmSanto Domingo Las Americas
$548
Copa Airlines
Mar 17
SDQ8:48 amSanto Domingo Las Americas
2h 42m
PTY10:30 amPanama City Tocumen Intl
Mar 31
PTY7:26 pmPanama City Tocumen Intl
2h 30m
SDQ10:56 pmSanto Domingo Las Americas
$579
Copa Airlines
Feb 6
SDQ8:50 amSanto Domingo Las Americas
2h 40m
PTY10:30 amPanama City Tocumen Intl
Feb 15
PTY2:37 pmPanama City Tocumen Intl
2h 28m
SDQ6:05 pmSanto Domingo Las Americas
$683

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/12

12:20 pm-4:55 pm

1 stop5h 35m

Panama City Tocumen Intl

Sun 2/15

9:45 am-4:50 pm

1 stop6h 05m

$454

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 2/21

12:20 pm-1:00 am

1 stop13h 40m

Panama City Tocumen Intl

Fri 2/27

2:55 am-4:50 pm

1 stop12h 55m

$455

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 2/7

5:45 pm-1:00 am

1 stop8h 15m

Panama City Tocumen Intl

Sat 12/19

2:55 am-4:50 pm

1 stop12h 55m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/12

12:20 pm-1:00 am

1 stop13h 40m

Panama City Tocumen Intl

Mon 2/16

9:45 am-4:50 pm

1 stop6h 05m

$483

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/21

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

Sun 4/26

10:05 pm-10:50 am

1 stop11h 45m

$501

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 3/4

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Fri 3/13

5:50 pm-11:25 am

1 stop16h 35m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 3/12

6:04 am-4:55 pm

2 stops11h 51m

Panama City Tocumen Intl

Thu 3/19

9:45 am-4:50 pm

1 stop6h 05m

$532

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 3/30

12:41 pm-12:45 am

2 stops13h 04m

Panama City Tocumen Intl

Fri 4/3

11:05 am-5:15 pm

1 stop5h 10m

$543

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/26

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Sun 3/1

5:50 pm-3:05 pm

2 stops20h 15m

$545

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/26

3:32 pm-2:00 pm

3 stops23h 28m

Panama City Tocumen Intl

Sat 2/28

2:55 am-4:50 pm

1 stop12h 55m

$546

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Santo Domingo to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and Panama City?

What is the cheapest month to fly to Panama City?

In general, May is the cheapest month to fly from Santo Domingo to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $429. If you’re not able to fly to Panama City in May, then June is your next best option. Flight prices from Santo Domingo to Panama City during June average around $463.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $384. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $507. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Santo Domingo to Panama City during this time can be as low as $415. Try not to purchase tickets in the evening because they tend to be around $525. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santo Domingo Las Americas to Panama City Tocumen Intl flight route?

Fly from Santo Domingo Las Americas to Panama City Tocumen Intl for the best Santo Domingo Las Americas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $498 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santo Domingo for as low as $371 on momondo.

What cabin class options are available on Santo Domingo Las Americas to Panama City Tocumen Intl flights?

There are 2 cabin classes available to choose from on Santo Domingo Las Americas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santo Domingo to Panama City flights?

You could potentially save up to 60% on your flight if you consider stops on a Santo Domingo to Panama City flight.

How have Santo Domingo to Panama City flight prices changed over time?

As of January 2026, prices for Santo Domingo to Panama City flights are approximately 79% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Panama City (SDQ to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Panama City

Best Price Found

$210

Fastest flight time

2h 35m

Direct flights

Tue, Wed, Thu and Sun

Airports in Panama City

1 airport
The best one-way flight to Panama City from Santo Domingo in the past 72 hours is $210. The best round-trip flight deal from Santo Domingo to Panama City found on momondo in the last 72 hours is $270.
The fastest flight from Santo Domingo to Panama City takes 2h 35m
Direct flights go from Santo Domingo to Panama City on Tuesday, Wednesday, Thursday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Panama City. From Santo Domingo there are direct flights to Panama City Tocumen Intl (PTY).
  • How far is Santo Domingo Las Americas to Panama City Tocumen Intl by plane?

    The straight-line distance from Santo Domingo Las Americas to Panama City Tocumen Intl is 918.3 mi. Flights usually cover this in 2h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santo Domingo to Panama City?

  • What is the most popular airline from Santo Domingo to Panama City?

Best airlines flying from Santo Domingo to Panama City

Compare and see reviews for airlines that fly from Santo Domingo to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $281Free CancellationRating
6.6
2,486 reviews
Search Avianca flights
Copa AirlinesPriceFrom $361Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
  • Copa Airlines Flights From Santo Domingo to Panama City

    Copa Airlines flies from Santo Domingo to Panama City around 27 times per week, with 1,560 momondo users rating the airline 7.5/10. The cheapest Copa Airlines deal from Santo Domingo to Panama City in the last 72 hours was $361 (round-trip), much lower than the average airfare cost of $524 for Copa Airlines flights on this route.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Why should I use momondo to find a flight deal from Santo Domingo to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santo Domingo to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santo Domingo to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Santo Domingo with this policy.

How can momondo help me find flights from Santo Domingo to Panama City?

Once all potential Santo Domingo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santo Domingo to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santo Domingo to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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1 adult
Fri 2/27
Fri 3/6

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