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Cheap flights from Santo Domingo to Panama City from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Panama City departing on 9/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Avianca Logo
11:45 am - 12:10 amSDQ-PTY
13h 25m1 stop
Avianca Logo
3:25 am - 10:50 amPTY-SDQ
6h 25m1 stop
$472Avianca
Find Deal
Thu, Oct 9 - Fri, Oct 10
Avianca Logo
6:10 pm - 10:10 amSDQ-PTY
17h 00m1 stop
Avianca Logo
3:20 am - 5:15 pmPTY-SDQ
12h 55m1 stop
$474Avianca
Find Deal
Tue, Sep 30 - Thu, Oct 23
Avianca Logo
11:45 am - 9:10 pmSDQ-PTY
10h 25m1 stop
Avianca Logo
9:45 am - 4:50 pmPTY-SDQ
6h 05m1 stop
$475Avianca
Find Deal
Tue, Sep 30 - Thu, Nov 27
Avianca Logo
5:45 pm - 8:50 amSDQ-PTY
16h 05m1 stop
Avianca Logo
2:55 am - 4:50 pmPTY-SDQ
12h 55m1 stop
$477Avianca
Find Deal
Wed, Nov 19 - Tue, Nov 25
Avianca Logo
5:45 pm - 12:40 amSDQ-PTY
7h 55m1 stop
Avianca Logo
9:45 am - 4:50 pmPTY-SDQ
6h 05m1 stop
$497Avianca
Find Deal
Fri, Nov 28 - Sun, Nov 30
Multiple Airlines Logo
3:50 pm - 12:45 amSDQ-PTY
33h 55m2 stops
Multiple Airlines Logo
11:00 am - 5:15 pmPTY-SDQ
5h 15m1 stop
$515Multiple Airlines
Find Deal
Tue, Sep 30 - Fri, Oct 24
Copa Airlines Logo
8:58 am - 10:30 amSDQ-PTY
2h 32mnonstop
Copa Airlines Logo
7:26 am - 10:56 amPTY-SDQ
2h 30mnonstop
$522Copa Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
Copa Airlines Logo
8:58 am - 10:30 amSDQ-PTY
2h 32mnonstop
Copa Airlines Logo
8:10 am - 11:32 amPTY-SDQ
2h 22mnonstop
$523Copa Airlines
Find Deal
Wed, Oct 1 - Tue, Jan 13
Copa Airlines Logo
11:55 am - 1:32 pmSDQ-PTY
2h 37mnonstop
Copa Airlines Logo
9:42 am - 1:12 pmPTY-SDQ
2h 30mnonstop
$525Copa Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 30
Copa Airlines Logo
6:24 pm - 7:55 pmSDQ-PTY
2h 31mnonstop
Copa Airlines Logo
6:55 pm - 10:25 pmPTY-SDQ
2h 30mnonstop
$534Copa Airlines
Find Deal
Fri, Oct 24 - Thu, Oct 30

Avianca flights from Santo Domingo to Panama City

Our best Avianca deals on Santo Domingo to Panama City flight tickets
Avianca
Oct 9
SDQ11:45 amSanto Domingo Las Americas
13h 25m
1 stop
PTY12:10 amPanama City Tocumen Intl
Oct 10
PTY3:25 amPanama City Tocumen Intl
6h 25m
1 stop
SDQ10:50 amSanto Domingo Las Americas
$472
Find similar
Avianca
Sep 30
SDQ6:10 pmSanto Domingo Las Americas
17h 00m
1 stop
PTY10:10 amPanama City Tocumen Intl
Oct 23
PTY3:20 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ5:15 pmSanto Domingo Las Americas
$474
Find similar
Avianca
Sep 30
SDQ11:45 amSanto Domingo Las Americas
10h 25m
1 stop
PTY9:10 pmPanama City Tocumen Intl
Nov 27
PTY9:45 amPanama City Tocumen Intl
6h 05m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
$475
Find similar

Copa Airlines flights from Santo Domingo to Panama City

Our best Copa Airlines deals on Santo Domingo to Panama City flight tickets
Copa Airlines
Oct 13
SDQ8:58 amSanto Domingo Las Americas
2h 32m
PTY10:30 amPanama City Tocumen Intl
Oct 20
PTY7:26 amPanama City Tocumen Intl
2h 30m
SDQ10:56 amSanto Domingo Las Americas
$522
Find similar
Copa Airlines
Oct 1
SDQ8:58 amSanto Domingo Las Americas
2h 32m
PTY10:30 amPanama City Tocumen Intl
Jan 13
PTY8:10 amPanama City Tocumen Intl
2h 22m
SDQ11:32 amSanto Domingo Las Americas
$523
Find similar
Copa Airlines
Nov 21
SDQ11:55 amSanto Domingo Las Americas
2h 37m
PTY1:32 pmPanama City Tocumen Intl
Nov 30
PTY9:42 amPanama City Tocumen Intl
2h 30m
SDQ1:12 pmSanto Domingo Las Americas
$525
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 10/9

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

Fri 10/10

3:25 am-10:50 am

1 stop6h 25m

$472

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 9/30

6:10 pm-10:10 am

1 stop17h 00m

Panama City Tocumen Intl

Thu 10/23

3:20 am-5:15 pm

1 stop12h 55m

$474

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 9/30

11:45 am-9:10 pm

1 stop10h 25m

Panama City Tocumen Intl

Thu 11/27

9:45 am-4:50 pm

1 stop6h 05m

$475

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/19

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Tue 11/25

2:55 am-4:50 pm

1 stop12h 55m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 11/28

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Sun 11/30

9:45 am-4:50 pm

1 stop6h 05m

$497

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 9/30

3:50 pm-12:45 am

2 stops33h 55m

Panama City Tocumen Intl

Fri 10/24

11:00 am-5:15 pm

1 stop5h 15m

$515

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 10/13

8:58 am-10:30 am

Nonstop2h 32m

Panama City Tocumen Intl

Mon 10/20

7:26 am-10:56 am

Nonstop2h 30m

$522

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 10/1

8:58 am-10:30 am

Nonstop2h 32m

Panama City Tocumen Intl

Tue 1/13

8:10 am-11:32 am

Nonstop2h 22m

$523

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 11/21

11:55 am-1:32 pm

Nonstop2h 37m

Panama City Tocumen Intl

Sun 11/30

9:42 am-1:12 pm

Nonstop2h 30m

$525

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/24

6:24 pm-7:55 pm

Nonstop2h 31m

Panama City Tocumen Intl

Thu 10/30

6:55 pm-10:25 pm

Nonstop2h 30m

$534

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Santo Domingo to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Santo Domingo to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $421. If you’re not able to fly to Panama City in November, then May is your next best option. Flight prices from Santo Domingo to Panama City during May average around $423.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $360. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $488. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Santo Domingo to Panama City during this time can be as low as $382. Try not to purchase tickets in the evening because they tend to be around $628. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santo Domingo Las Americas to Panama City Tocumen Intl flight route?

Fly from Santo Domingo Las Americas to Panama City Tocumen Intl for the best Santo Domingo Las Americas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $473 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santo Domingo for as low as $330 on momondo.

What cabin class options are available on Santo Domingo Las Americas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Santo Domingo Las Americas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Santo Domingo to Panama City flight prices changed over time?

As of September 2025, prices for Santo Domingo to Panama City flights are approximately 33% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Panama City (SDQ to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Panama City

Best Price Found

$255

Fastest flight time

2h 31m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Santo Domingo in the past 72 hours is $255. The best round-trip flight deal from Santo Domingo to Panama City found on momondo in the last 72 hours is $331.
The fastest flight from Santo Domingo to Panama City takes 2h 31m
Direct flights go from Santo Domingo to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Santo Domingo Las Americas to Panama City Tocumen Intl by plane?

    The straight-line distance from Santo Domingo Las Americas to Panama City Tocumen Intl is 918.3 mi. Flights usually cover this in 2h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santo Domingo to Panama City?

  • What is the most popular airline from Santo Domingo to Panama City?

Best airlines flying from Santo Domingo to Panama City

Compare and see reviews for airlines that fly from Santo Domingo to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $281Free CancellationRating
6.7
2,435 reviews
Search Avianca flights
Copa AirlinesPriceFrom $419Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Santo Domingo to Panama City

    Copa Airlines flies from Santo Domingo to Panama City around 25 times per week, with 1,531 momondo users rating the airline 7.6/10. The cheapest Copa Airlines deal from Santo Domingo to Panama City in the last 72 hours was $419 (round-trip), much lower than the average airfare cost of $498 for Copa Airlines flights on this route.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santo Domingo to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santo Domingo to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Santo Domingo with this policy.

How can momondo help me find flights from Santo Domingo to Panama City?

Once all potential Santo Domingo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santo Domingo to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santo Domingo to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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