Cheap flights from Santo Domingo to Madrid from $397

The month of October is, on average, the cheapest month to fly to Madrid from Santo Domingo, with most prices found around $795. If you don’t want to visit Madrid in October, then you should wait until November to fly from Santo Domingo, when ticket prices are also cheap, with an average price of $836.

The cheapest day to depart on your flight to Madrid is on a Sunday when prices can be found for as low as $944. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Madrid on Friday is $1,147.

Flying to Madrid from Santo Domingo in the evening is the least expensive time of day to depart. momondo users have found prices as low as $993 when looking at flights departing in the evening. Flights to Madrid are more costly in the afternoon, with an average ticket price of $1,121. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Santo Domingo Las Americas to Madrid Barajas for the best Santo Domingo Las Americas - Madrid Barajas flight prices

You are more likely to see cheaper flights to Madrid from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Madrid for around $923 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Madrid from Santo Domingo for as low as $821 on momondo.

There are 3 cabin classes available to choose from on Santo Domingo to Madrid flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

World2Fly, Iberia, and United Airlines are the most popular carriers operating from Santo Domingo Las Americas to Madrid Barajas

Iberia, World2Fly and Air Europa are the top three most popular airlines that fly to Madrid from Santo Domingo according to our data. Iberia is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Madrid. Keep in mind that there are 4 different airlines that fly to Madrid on a routine basis, so you have a few additional options to choose from.

Historically, on average around 19% of flights between Santo Domingo and Madrid have experienced a delay on any given week. The average delay length over the past 12 months has been 135 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Sunday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, Air Europa have had the least number of delays on this route over the last 12 months; with about 11% of their flights experiencing any sort of delay.

As of July 2026, 10 flights take off from Santo Domingo and land in Madrid each day. The most common flight departure time for this route is 9:00PM, with 69% of daily flights taking off in the evening.

As of July 2026, there are 75 flights per week flying from Santo Domingo to Madrid. The most common day of the week flights depart is Tue, with 17% of flights taking off on this day.