Cheap flights from Massachusetts to Panama City from $262

In general, May is the cheapest month to fly from Massachusetts to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $610. If you’re not able to fly to Panama City in May, then March is your next best option. Flight prices from Massachusetts to Panama City during March average around $646.

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $600. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $720. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Massachusetts to Panama City during this time can be as low as $550. Try not to purchase tickets at noon because they tend to be around $738. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Boston Logan Intl to Panama City Tocumen Intl for the best Massachusetts - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Massachusetts when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $716 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Massachusetts for as low as $594 on momondo.

There are 3 cabin classes available to choose from on Massachusetts to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

American Airlines and Aeromexico are the most popular carriers operating from Massachusetts to Panama City Tocumen Intl

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama City from Massachusetts according to our data. Copa Airlines is the first choice among our users, with 89% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

The number of flights available between Massachusetts and Panama City is 2 per day as of October 2026. The most frequent departure time is 8:00AM, with 100% of daily flights leaving at noon.

The number of flights available between Massachusetts and Panama City is 18 per week as of October 2026. The most frequent departure day is Mon, with 17% of weekly flights leaving on this day.