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Cheap flights from Madrid to Panama City from $331

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Madrid to Panama City departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Madrid to Panama City

Cheap round-trip flights

Avianca Logo
1:30 am - 10:10 amMAD-PTY
15h 40m1 stop
Avianca Logo
3:19 am - 6:30 amPTY-MAD
21h 11m1 stop
$680Avianca
Find Deal
Sun, Oct 19 - Wed, Oct 29
Avianca Logo
5:30 pm - 12:10 amMAD-PTY
13h 40m1 stop
Avianca Logo
11:25 am - 8:55 amPTY-MAD
15h 30m1 stop
$687Avianca
Find Deal
Sun, Oct 5 - Sun, Oct 26
Air Europa Logo
3:10 pm - 7:45 pmMAD-PTY
10h 35mnonstop
Air Europa Logo
9:30 pm - 1:05 pmPTY-MAD
9h 35mnonstop
$699Air Europa
Find Deal
Tue, Nov 11 - Wed, Nov 26
 Logo
10:20 am - 4:50 pmMAD-PTY
37h 30m1 stop
 Logo
7:55 pm - 4:45 pmPTY-MAD
13h 50m1 stop
Sun, Jun 22 - Tue, Jul 1
Air Europa Logo
3:10 pm - 7:45 pmMAD-PTY
10h 35mnonstop
Air Europa Logo
9:30 pm - 1:05 pmPTY-MAD
9h 35mnonstop
$734Air Europa
Find Deal
Wed, Nov 12 - Sun, Nov 23
KLM Logo
10:20 am - 4:50 pmMAD-PTY
37h 30m1 stop
KLM Logo
6:50 pm - 9:35 amPTY-MAD
31h 45m1 stop
$744KLM
Find Deal
Sun, Jun 22 - Sun, Jun 29
KLM Logo
1:05 pm - 4:50 pmMAD-PTY
34h 45m1 stop
KLM Logo
6:50 pm - 9:35 amPTY-MAD
31h 45m1 stop
$758KLM
Find Deal
Fri, Aug 22 - Thu, Sep 18
 Logo
8:25 pm - 4:50 pmMAD-PTY
27h 25m1 stop
 Logo
7:55 pm - 4:45 pmPTY-MAD
13h 50m1 stop
Tue, Jul 8 - Tue, Jul 22
Iberia Logo
12:00 pm - 3:40 pmMAD-PTY
10h 40mnonstop
Iberia Logo
5:10 pm - 10:15 amPTY-MAD
10h 05mnonstop
$870Iberia
Find Deal
Thu, Aug 28 - Sat, Sep 13
Iberia Logo
12:00 pm - 3:40 pmMAD-PTY
10h 40mnonstop
Iberia Logo
3:34 pm - 12:45 pmPTY-MAD
14h 11m1 stop
$894Iberia
Find Deal
Mon, Aug 25 - Mon, Sep 15

Air Europa flights from Madrid to Panama City

Our best Air Europa deals on Madrid to Panama City flight tickets
Air Europa
Nov 11
MAD3:10 pmMadrid Barajas
10h 35m
PTY7:45 pmPanama City Tocumen Intl
Nov 26
PTY9:30 pmPanama City Tocumen Intl
9h 35m
MAD1:05 pmMadrid Barajas
Air Europa
Nov 12
MAD3:10 pmMadrid Barajas
10h 35m
PTY7:45 pmPanama City Tocumen Intl
Nov 23
PTY9:30 pmPanama City Tocumen Intl
9h 35m
MAD1:05 pmMadrid Barajas
Air Europa
Aug 28
MAD3:05 pmMadrid Barajas
10h 35m
PTY6:40 pmPanama City Tocumen Intl
Sep 13
PTY8:25 pmPanama City Tocumen Intl
9h 50m
MAD1:15 pmMadrid Barajas

KLM flights from Madrid to Panama City

Our best KLM deals on Madrid to Panama City flight tickets
KLM
Jun 22
MAD10:20 amMadrid Barajas
37h 30m
1 stop
PTY4:50 pmPanama City Tocumen Intl
Jun 29
PTY6:50 pmPanama City Tocumen Intl
31h 45m
1 stop
MAD9:35 amMadrid Barajas
KLM
Aug 22
MAD1:05 pmMadrid Barajas
34h 45m
1 stop
PTY4:50 pmPanama City Tocumen Intl
Sep 18
PTY6:50 pmPanama City Tocumen Intl
31h 45m
1 stop
MAD9:35 amMadrid Barajas
KLM
Sep 8
MAD5:10 pmMadrid Barajas
30h 40m
1 stop
PTY4:50 pmPanama City Tocumen Intl
Sep 18
PTY6:50 pmPanama City Tocumen Intl
31h 45m
1 stop
MAD9:35 amMadrid Barajas

See travel insights to Panama City from

How to get the cheapest flight ticket from Madrid to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Madrid and Panama City?

What is the cheapest month to fly to Panama City?

In general, March is the cheapest month to fly from Madrid to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $666. If you’re not able to fly to Panama City in March, then September is your next best option. Flight prices from Madrid to Panama City during September average around $670.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $783. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $1,022. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Madrid to Panama City during this time can be as low as $817. Try not to purchase tickets in the afternoon because they tend to be around $895. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Madrid Barajas to Panama City Tocumen Intl flight route?

Fly from Madrid Barajas to Panama City Tocumen Intl for the best Madrid Barajas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Madrid when booking 25 weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $802 when searching 25 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Madrid for as low as $693 on momondo.

What cabin class options are available on Madrid Barajas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Madrid Barajas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Madrid to Panama City flight prices changed over time?

As of June 2025, prices for Madrid to Panama City flights are approximately 90% more expensive when compared to flights at the same time last year.

When to book flights from Madrid to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Madrid to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Madrid to Panama City (MAD to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Madrid to Panama City

Best Price Found

$331

Fastest flight time

10h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Madrid in the past 72 hours is $331. The best round-trip flight deal from Madrid to Panama City found on momondo in the last 72 hours is $680.
The fastest flight from Madrid to Panama City takes 10h 35m
Direct flights go from Madrid to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)

  • How far is Madrid Barajas to Panama City Tocumen Intl by plane?

    The straight-line distance from Madrid Barajas to Panama City Tocumen Intl is 5069.0 mi. 10h 35m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Madrid Barajas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Madrid to Panama City?

  • What is the most popular airline from Madrid to Panama City?


Best airlines flying from Madrid to Panama City

Compare and see reviews for airlines that fly from Madrid to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $582Free CancellationRating
6.7
2,345 reviews
Search Avianca flights
Air EuropaPriceFrom $630Free CancellationRating
6.9
529 reviews
Search Air Europa flights
IberiaPriceFrom $644Free CancellationRating
7.0
2,776 reviews
Search Iberia flights
  • Iberia Flights From Madrid to Panama City

    Iberia flies from Madrid to Panama City around 2 times per week, with 2,776 momondo users rating the airline 7.0/10. The cheapest Iberia deal from Madrid to Panama City in the last 72 hours was $644 (round-trip), much lower than the average airfare cost of $796 for Iberia flights on this route.

  • Air Europa Flights From Madrid to Panama City

    Another popular option for Madrid to Panama City flights is Air Europa (6.9/10, 529 ratings). Air Europa flies from Madrid to Panama City around 5 times per week, with deals starting from $630 round-trip and rising to an average price of around $879.


Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Madrid to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Madrid to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Madrid to Panama City with flexible booking policies on momondo?

All flight searches from Madrid to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Madrid to Panama City?

Once you have performed a search for Madrid to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Madrid to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Madrid are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.


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1 adult
Tue 6/17
Tue 6/24

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