Cheap flights from Madrid to Panama City from $356

In general, April is the cheapest month to fly from Madrid to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $734. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from Madrid to Panama City during May average around $741.

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $758. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $1,360. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Madrid to Panama City during this time can be as low as $1,030. Try not to purchase tickets in the afternoon because they tend to be around $1,043. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Madrid Barajas to Panama City Tocumen Intl for the best Madrid Barajas - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $849 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Madrid for as low as $773 on momondo.

There are 3 cabin classes available to choose from on Madrid to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Madrid to Panama City.

As of May 2026, prices for Madrid to Panama City flights are approximately 19% cheaper when compared to flights at the same time last year.

Avianca, Iberia, and KLM are the most popular carriers operating from Madrid Barajas to Panama City Tocumen Intl

Air Europa, Iberia and Avianca are the top three most popular airlines that fly to Panama City from Madrid according to our data. Air Europa is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 24% of flights between Madrid and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 129 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, Iberia have had the least number of delays on this route over the last 12 months; with about 25% of their flights experiencing any sort of delay.

The number of flights available between Madrid and Panama City is 5 per day as of May 2026. The most frequent departure time is 3:00PM, with 100% of daily flights leaving in the afternoon.

41 flights are operational weekly from Madrid to Panama City as of May 2026. The most popular departure day for this route is Fri, with 27% of flights per week taking off on this day.