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Cheap flights from Madrid to Panama City from $308

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Madrid to Panama City departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Air France Logo
6:00 am - 5:45 pmMAD-PTY
18h 45m1 stop
Air France Logo
7:55 pm - 9:10 amPTY-MAD
30h 15m1 stop
$586Air France
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Thu, Sep 11 - Mon, Sep 29
Logo
8:25 pm - 4:50 pmMAD-PTY
27h 25m1 stop
Logo
7:55 pm - 4:45 pmPTY-MAD
13h 50m1 stop
$591
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Fri, Sep 12 - Mon, Sep 22
Logo
6:00 am - 4:50 pmMAD-PTY
17h 50m1 stop
Logo
7:55 pm - 4:45 pmPTY-MAD
13h 50m1 stop
$611
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Tue, Sep 16 - Mon, Sep 29
Air Europa Logo
3:05 pm - 6:40 pmMAD-PTY
10h 35mnonstop
Air Europa Logo
8:25 pm - 1:15 pmPTY-MAD
9h 50mnonstop
$624Air Europa
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Fri, Sep 12 - Sun, Sep 28
Air Europa Logo
3:05 pm - 6:40 pmMAD-PTY
10h 35mnonstop
Air Europa Logo
8:25 pm - 1:15 pmPTY-MAD
9h 50mnonstop
$642Air Europa
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Tue, Sep 9 - Sun, Sep 28
Avianca Logo
9:40 am - 4:30 pmMAD-PTY
13h 50m1 stop
Avianca Logo
9:55 am - 7:40 amPTY-MAD
14h 45m1 stop
$651Avianca
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Tue, Sep 9 - Tue, Sep 16
Avianca Logo
1:20 am - 2:00 pmMAD-PTY
18h 40m1 stop
Avianca Logo
2:55 pm - 11:20 pmPTY-MAD
26h 25m1 stop
$652Avianca
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Mon, Feb 9 - Mon, Feb 23
United Airlines Logo
6:00 am - 2:45 pmMAD-PTY
38h 45m2 stops
United Airlines Logo
4:41 pm - 8:05 amPTY-MAD
57h 24m2 stops
$668United Airlines
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Thu, Nov 13 - Thu, Nov 27
United Airlines Logo
11:05 am - 1:55 pmMAD-PTY
32h 50m2 stops
United Airlines Logo
4:41 pm - 9:15 amPTY-MAD
34h 34m2 stops
$681United Airlines
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Fri, Nov 14 - Thu, Dec 4
KLM Logo
8:25 pm - 4:50 pmMAD-PTY
27h 25m1 stop
KLM Logo
6:50 pm - 4:25 pmPTY-MAD
14h 35m1 stop
$704KLM
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Sun, Sep 7 - Tue, Sep 23

Avianca flights from Madrid to Panama City

Our best Avianca deals on Madrid to Panama City flight tickets
Avianca
Sep 9
MAD9:40 amMadrid Barajas
13h 50m
1 stop
PTY4:30 pmPanama City Tocumen Intl
Sep 16
PTY9:55 amPanama City Tocumen Intl
14h 45m
1 stop
MAD7:40 amMadrid Barajas
$651
Find similar
Avianca
Feb 9
MAD1:20 amMadrid Barajas
18h 40m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Feb 23
PTY2:55 pmPanama City Tocumen Intl
26h 25m
1 stop
MAD11:20 pmMadrid Barajas
$652
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Avianca
Jan 23
MAD10:55 amMadrid Barajas
16h 05m
1 stop
PTY9:00 pmPanama City Tocumen Intl
Jan 31
PTY2:55 amPanama City Tocumen Intl
19h 40m
1 stop
MAD4:35 amMadrid Barajas
$653
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United Airlines flights from Madrid to Panama City

Our best United Airlines deals on Madrid to Panama City flight tickets
United Airlines
Nov 13
MAD6:00 amMadrid Barajas
38h 45m
2 stops
PTY2:45 pmPanama City Tocumen Intl
Nov 27
PTY4:41 pmPanama City Tocumen Intl
57h 24m
2 stops
MAD8:05 amMadrid Barajas
$668
Find similar
United Airlines
Nov 14
MAD11:05 amMadrid Barajas
32h 50m
2 stops
PTY1:55 pmPanama City Tocumen Intl
Dec 4
PTY4:41 pmPanama City Tocumen Intl
34h 34m
2 stops
MAD9:15 amMadrid Barajas
$681
Find similar
United Airlines
Oct 9
MAD11:15 amMadrid Barajas
33h 35m
2 stops
PTY1:50 pmPanama City Tocumen Intl
Oct 20
PTY9:45 amPanama City Tocumen Intl
16h 15m
1 stop
MAD9:00 amMadrid Barajas
$682
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momondo Fare Finder

 
Customize your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 9/11

6:00 am-5:45 pm

1 stop18h 45m

Panama City Tocumen Intl

Mon 9/29

7:55 pm-9:10 am

1 stop30h 15m

$586

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 9/12

8:25 pm-4:50 pm

1 stop27h 25m

Panama City Tocumen Intl

Mon 9/22

7:55 pm-4:45 pm

1 stop13h 50m

$591

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 9/16

6:00 am-4:50 pm

1 stop17h 50m

Panama City Tocumen Intl

Mon 9/29

7:55 pm-4:45 pm

1 stop13h 50m

$611

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 9/12

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

$624

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 9/9

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Sun 9/28

8:25 pm-1:15 pm

Nonstop9h 50m

$642

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 9/9

9:40 am-4:30 pm

1 stop13h 50m

Panama City Tocumen Intl

Tue 9/16

9:55 am-7:40 am

1 stop14h 45m

$651

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 2/9

1:20 am-2:00 pm

1 stop18h 40m

Panama City Tocumen Intl

Mon 2/23

2:55 pm-11:20 pm

1 stop26h 25m

$652

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 11/13

6:00 am-2:45 pm

2 stops38h 45m

Panama City Tocumen Intl

Thu 11/27

4:41 pm-8:05 am

2 stops57h 24m

$668

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 11/14

11:05 am-1:55 pm

2 stops32h 50m

Panama City Tocumen Intl

Thu 12/4

4:41 pm-9:15 am

2 stops34h 34m

$681

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 9/7

8:25 pm-4:50 pm

1 stop27h 25m

Panama City Tocumen Intl

Tue 9/23

6:50 pm-4:25 pm

1 stop14h 35m

$704

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Madrid to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, March is the cheapest month to fly from Madrid to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $667. If you’re not able to fly to Panama City in March, then February is your next best option. Flight prices from Madrid to Panama City during February average around $690.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $707. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $1,030. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Madrid to Panama City during this time can be as low as $848. Try not to purchase tickets in the afternoon because they tend to be around $881. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Madrid Barajas to Panama City Tocumen Intl flight route?

Fly from Madrid Barajas to Panama City Tocumen Intl for the best Madrid Barajas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $805 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Madrid for as low as $704 on momondo.

What cabin class options are available on Madrid Barajas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Madrid Barajas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Madrid to Panama City flights?

You could potentially save up to 12% on your flight if you consider stops on a Madrid to Panama City flight.

How have Madrid to Panama City flight prices changed over time?

As of August 2025, prices for Madrid to Panama City flights are approximately 21% cheaper when compared to flights at the same time last year.

When to book flights from Madrid to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Madrid to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Madrid to Panama City (MAD to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Madrid to Panama City

Best Price Found

$308

Fastest flight time

10h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Madrid in the past 72 hours is $308. The best round-trip flight deal from Madrid to Panama City found on momondo in the last 72 hours is $586.
The fastest flight from Madrid to Panama City takes 10h 35m
Direct flights go from Madrid to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
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  • How far is Madrid Barajas to Panama City Tocumen Intl by plane?

    The straight-line distance from Madrid Barajas to Panama City Tocumen Intl is 5069.0 mi. 10h 35m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Madrid Barajas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Madrid to Panama City?

  • What is the most popular airline from Madrid to Panama City?

Best airlines flying from Madrid to Panama City

Compare and see reviews for airlines that fly from Madrid to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $582Free CancellationRating
6.7
2,399 reviews
Search Avianca flights
Air EuropaPriceFrom $623Free CancellationRating
7.0
543 reviews
Search Air Europa flights
IberiaPriceFrom $644Free CancellationRating
7.0
2,878 reviews
Search Iberia flights

  • Air Europa Flights From Madrid to Panama City

    Air Europa flies from Madrid to Panama City around 6 times per week, with 545 momondo users rating the airline 7.0/10. The cheapest Air Europa deal from Madrid to Panama City in the last 72 hours was $623 (round-trip), much lower than the average airfare cost of $866 for Air Europa flights on this route.

  • Iberia Flights From Madrid to Panama City

    Another popular option for Madrid to Panama City flights is Iberia (7.0/10, 2,878 ratings). Iberia flies from Madrid to Panama City around 4 times per week, with deals starting from $644 round-trip and rising to an average price of around $793.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Madrid to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Madrid to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Madrid to Panama City with flexible booking policies on momondo?

All flight searches from Madrid to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Madrid to Panama City?

Once you have performed a search for Madrid to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Madrid to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Madrid are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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