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Cheap flights from Houston to Panama City from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Panama City departing on 11/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Houston to Panama City

Cheap round-trip flights

Logo
5:30 am - 9:10 pmIAH-PTY
15h 40m2 stops
Logo
5:25 pm - 10:42 pmPTY-IAH
29h 17m2 stops
$389
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Mon, Sep 1 - Tue, Sep 16
Logo
5:25 am - 12:10 amIAH-PTY
18h 45m2 stops
Logo
5:25 pm - 12:24 amPTY-IAH
30h 59m2 stops
$401
Find Deal
Thu, Oct 2 - Fri, Oct 17
Logo
10:54 am - 7:29 pmIAH-PTY
8h 35m1 stop
Logo
9:33 pm - 9:54 amPTY-IAH
12h 21m1 stop
$413
Find Deal
Sat, Sep 6 - Thu, Sep 11
Delta Logo
6:00 am - 12:55 pmHOU-PTY
6h 55m1 stop
Delta Logo
2:10 pm - 9:49 amPTY-HOU
19h 39m1 stop
$746Delta
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Mon, Sep 15 - Mon, Sep 22
Delta Logo
6:00 am - 12:55 pmHOU-PTY
6h 55m1 stop
Delta Logo
2:21 pm - 11:00 pmPTY-HOU
8h 39m1 stop
$753Delta
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Tue, Sep 30 - Tue, Oct 7
American Airlines Logo
2:33 pm - 12:55 pmHOU-PTY
22h 22m2 stops
American Airlines Logo
1:45 pm - 9:44 amPTY-HOU
19h 59m2 stops
$758American Airlines
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Tue, Sep 23 - Tue, Sep 30
American Airlines Logo
6:44 pm - 12:55 pmHOU-PTY
18h 11m2 stops
American Airlines Logo
3:15 pm - 8:28 amPTY-HOU
17h 13m2 stops
$759American Airlines
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Tue, Sep 30 - Tue, Oct 7
Delta Logo
6:00 am - 1:56 pmHOU-PTY
6h 56m1 stop
Delta Logo
3:17 pm - 9:23 amPTY-HOU
19h 06m1 stop
$765Delta
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Thu, Nov 6 - Thu, Nov 13
American Airlines Logo
6:30 pm - 1:20 pmHOU-PTY
17h 50m2 stops
American Airlines Logo
4:40 pm - 8:38 amPTY-HOU
16h 58m2 stops
$778American Airlines
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Sat, Jan 3 - Tue, Feb 3
American Airlines Logo
4:28 pm - 12:55 pmHOU-PTY
20h 27m2 stops
American Airlines Logo
3:31 pm - 9:44 amPTY-HOU
18h 13m2 stops
$779American Airlines
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Mon, Sep 15 - Mon, Sep 22

American Airlines flights from Houston to Panama City

Our best American Airlines deals on Houston to Panama City flight tickets
American Airlines
Sep 23
HOU2:33 pmHouston Hobby
22h 22m
2 stops
PTY12:55 pmPanama City Tocumen Intl
Sep 30
PTY1:45 pmPanama City Tocumen Intl
19h 59m
2 stops
HOU9:44 amHouston Hobby
$758
Find similar
American Airlines
Sep 30
HOU6:44 pmHouston Hobby
18h 11m
2 stops
PTY12:55 pmPanama City Tocumen Intl
Oct 7
PTY3:15 pmPanama City Tocumen Intl
17h 13m
2 stops
HOU8:28 amHouston Hobby
$759
Find similar
American Airlines
Jan 3
HOU6:30 pmHouston Hobby
17h 50m
2 stops
PTY1:20 pmPanama City Tocumen Intl
Feb 3
PTY4:40 pmPanama City Tocumen Intl
16h 58m
2 stops
HOU8:38 amHouston Hobby
$778
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Delta flights from Houston to Panama City

Our best Delta deals on Houston to Panama City flight tickets
Delta
Sep 15
HOU6:00 amHouston Hobby
6h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 22
PTY2:10 pmPanama City Tocumen Intl
19h 39m
1 stop
HOU9:49 amHouston Hobby
$746
Find similar
Delta
Sep 30
HOU6:00 amHouston Hobby
6h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Oct 7
PTY2:21 pmPanama City Tocumen Intl
8h 39m
1 stop
HOU11:00 pmHouston Hobby
$753
Find similar
Delta
Nov 6
HOU6:00 amHouston Hobby
6h 56m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 13
PTY3:17 pmPanama City Tocumen Intl
19h 06m
1 stop
HOU9:23 amHouston Hobby
$765
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momondo Fare Finder

 
Customize your flight search to find flights from Houston to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Houston to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Mon 9/1

5:30 am-9:10 pm

2 stops15h 40m

Panama City Tocumen Intl

Tue 9/16

5:25 pm-10:42 pm

2 stops29h 17m

$389

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Thu 10/2

5:25 am-12:10 am

2 stops18h 45m

Panama City Tocumen Intl

Fri 10/17

5:25 pm-12:24 am

2 stops30h 59m

$401

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Sat 9/6

10:54 am-7:29 pm

1 stop8h 35m

Panama City Tocumen Intl

Thu 9/11

9:33 pm-9:54 am

1 stop12h 21m

$413

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Mon 9/15

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Mon 9/22

2:10 pm-9:49 am

1 stop19h 39m

$746

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Tue 9/30

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Tue 10/7

2:21 pm-11:00 pm

1 stop8h 39m

$753

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Tue 9/23

2:33 pm-12:55 pm

2 stops22h 22m

Panama City Tocumen Intl

Tue 9/30

1:45 pm-9:44 am

2 stops19h 59m

$758

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Tue 9/30

6:44 pm-12:55 pm

2 stops18h 11m

Panama City Tocumen Intl

Tue 10/7

3:15 pm-8:28 am

2 stops17h 13m

$759

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Thu 11/6

6:00 am-1:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Thu 11/13

3:17 pm-9:23 am

1 stop19h 06m

$765

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Sat 1/3

6:30 pm-1:20 pm

2 stops17h 50m

Panama City Tocumen Intl

Tue 2/3

4:40 pm-8:38 am

2 stops16h 58m

$778

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Mon 9/15

4:28 pm-12:55 pm

2 stops20h 27m

Panama City Tocumen Intl

Mon 9/22

3:31 pm-9:44 am

2 stops18h 13m

$779

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Houston to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Panama City?

What is the cheapest month to fly to Panama City?

In general, January is the cheapest month to fly from Houston to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $788. If you’re not able to fly to Panama City in January, then October is your next best option. Flight prices from Houston to Panama City during October average around $828.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Saturday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $802. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $1,137. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Houston to Panama City during this time can be as low as $467. Try not to purchase tickets in the morning because they tend to be around $1,040. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Houston to Panama City Tocumen Intl flight route?

Fly from Houston George Bush Intcntl to Panama City Tocumen Intl for the best Houston - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Houston when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $881 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Houston for as low as $435 on momondo.

What cabin class options are available on Houston to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Houston to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Panama City

Best Price Found

$159

Fastest flight time

4h 11m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Houston in the past 72 hours is $159. The best round-trip flight deal from Houston to Panama City found on momondo in the last 72 hours is $389.
The fastest flight from Houston to Panama City takes 4h 11m
Direct flights go from Houston to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Houston to Panama City Tocumen Intl by plane?

    Houston and Panama City Tocumen Intl are 1762.1 mi apart from one another. A reasonable flight in good conditions will take 6h 27m.

  • When did momondo last update prices for flights from Houston to Panama City Tocumen Intl Airport?

    Prices for flights from Houston to Panama City Tocumen Intl Airport refresh daily.

  • How many operators does momondo search for flights from Houston to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Houston to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Panama City

Compare and see reviews for airlines that fly from Houston to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $318Free CancellationRating
6.7
2,407 reviews
Search Avianca flights
United AirlinesPriceFrom $738Free CancellationRating
7.4
8,925 reviews
Search United Airlines flights
American AirlinesPriceFrom $753Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $825Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Houston to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Houston to Panama City with flexible booking policies on momondo?

Flights from Houston to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Houston to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Houston.

I’m not ready to book a flight from Houston to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Houston are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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