Cheap flights from Houston to Panama City from $263

In general, April is the cheapest month to fly from Houston to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $452. If you’re not able to fly to Panama City in April, then September is your next best option. Flight prices from Houston to Panama City during September average around $483.

Our most recent data shows that the best time of day to fly to Panama City is at noon. Flights from Houston to Panama City during this time can be as low as $858. Try not to purchase tickets in the morning because they tend to be around $912. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Houston George Bush Intcntl to Panama City Tocumen Intl for the best Houston - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Houston when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $912 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Houston for as low as $636 on momondo.

Historically, on average around 17% of flights between Houston and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 138 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Wednesday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 17% of their flights experiencing any sort of delay.

The number of flights available between Houston and Panama City is 6 per day as of May 2026. The most frequent departure time is 9:00AM, with 66% of daily flights leaving at noon.

The number of flights available between Houston and Panama City is 42 per week as of May 2026. The most frequent departure day is Mon, with 14% of weekly flights leaving on this day.