Cheap flights from Houston to Panama City from $279

In general, March is the cheapest month to fly from Houston to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $818. If you’re not able to fly to Panama City in March, then January is your next best option. Flight prices from Houston to Panama City during January average around $850.

Our most recent data shows that the best time of day to fly to Panama City is at noon. Flights from Houston to Panama City during this time can be as low as $886. Try not to purchase tickets in the morning because they tend to be around $923. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Houston George Bush Intcntl to Panama City Tocumen Intl for the best Houston - Panama City Tocumen Intl flight prices

There are 3 cabin classes available to choose from on Houston to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

American Airlines is the most popular carrier operating from Houston to Panama City Tocumen Intl

United Airlines, Copa Airlines and JetBlue are the top three most popular airlines that fly to Panama City from Houston according to our data. United Airlines is the first choice among our users, with 77% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 18% of flights between Houston and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 130 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 18% of their flights experiencing any sort of delay.

The number of flights available between Houston and Panama City is 6 per day as of July 2026. The most frequent departure time is 9:00AM, with 66% of daily flights leaving at noon.

The number of flights available between Houston and Panama City is 42 per week as of July 2026. The most frequent departure day is Mon, with 14% of weekly flights leaving on this day.