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Cheap flights from Detroit Metropolitan Wayne County Airport to Panama City from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Panama City departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Panama City

Cheap round-trip flights

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Multiple Airlines Logo
6:35 am - 12:40 amDTW-PTY
18h 05m2 stops
Multiple Airlines Logo
9:45 am - 10:12 pmPTY-DTW
12h 27m2 stops
$516Multiple Airlines
Find Deal
Mon, Feb 2 - Sun, Feb 8
Multiple Airlines Logo
6:35 am - 12:40 amDTW-PTY
18h 05m2 stops
Multiple Airlines Logo
2:55 am - 10:44 pmPTY-DTW
19h 49m2 stops
$531Multiple Airlines
Find Deal
Wed, Jan 21 - Mon, Jan 26
Multiple Airlines Logo
11:07 am - 8:37 pmDTW-PTY
9h 30m1 stop
Multiple Airlines Logo
5:50 pm - 3:34 pmPTY-DTW
21h 44m2 stops
$539Multiple Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
American Airlines Logo
5:35 am - 1:40 pmDTW-PTY
8h 05m1 stop
American Airlines Logo
2:52 pm - 11:53 pmPTY-DTW
9h 01m1 stop
$609American Airlines
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Tue, Feb 17 - Tue, Mar 3
American Airlines Logo
5:24 pm - 1:40 pmDTW-PTY
20h 16m2 stops
American Airlines Logo
2:52 pm - 10:39 amPTY-DTW
19h 47m2 stops
$613American Airlines
Find Deal
Tue, Feb 17 - Tue, Mar 3
American Airlines Logo
5:35 am - 3:14 pmDTW-PTY
9h 39m1 stop
American Airlines Logo
3:50 pm - 10:47 amPTY-DTW
17h 57m2 stops
$638American Airlines
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Fri, Mar 6 - Sun, Mar 15
United Airlines Logo
6:06 pm - 5:10 amDTW-PTY
11h 04m2 stops
United Airlines Logo
9:30 am - 8:17 pmPTY-DTW
9h 47m1 stop
$643United Airlines
Find Deal
Sat, Mar 7 - Tue, Mar 17
American Airlines Logo
5:35 am - 3:14 pmDTW-PTY
9h 39m1 stop
American Airlines Logo
1:50 pm - 4:53 pmPTY-DTW
26h 03m1 stop
$649American Airlines
Find Deal
Fri, Mar 6 - Sun, Mar 15
United Airlines Logo
6:49 pm - 4:10 amDTW-PTY
10h 21m1 stop
United Airlines Logo
10:55 pm - 10:52 amPTY-DTW
10h 57m1 stop
$659United Airlines
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Sat, Mar 14 - Sun, Mar 22
United Airlines Logo
2:15 pm - 4:10 amDTW-PTY
14h 55m2 stops
United Airlines Logo
3:41 pm - 1:25 pmPTY-DTW
20h 44m2 stops
$663United Airlines
Find Deal
Sat, Mar 14 - Sun, Mar 22

American Airlines flights from Detroit Metropolitan Wayne County Airport to Panama City

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Panama City flight tickets
American Airlines
Feb 17
DTW5:35 amDetroit Metropolitan Wayne County
8h 05m
1 stop
PTY1:40 pmPanama City Tocumen Intl
Mar 3
PTY2:52 pmPanama City Tocumen Intl
9h 01m
1 stop
DTW11:53 pmDetroit Metropolitan Wayne County
$609
Find similar
American Airlines
Feb 17
DTW5:24 pmDetroit Metropolitan Wayne County
20h 16m
2 stops
PTY1:40 pmPanama City Tocumen Intl
Mar 3
PTY2:52 pmPanama City Tocumen Intl
19h 47m
2 stops
DTW10:39 amDetroit Metropolitan Wayne County
$613
Find similar
American Airlines
Mar 6
DTW5:35 amDetroit Metropolitan Wayne County
9h 39m
1 stop
PTY3:14 pmPanama City Tocumen Intl
Mar 15
PTY3:50 pmPanama City Tocumen Intl
17h 57m
2 stops
DTW10:47 amDetroit Metropolitan Wayne County
$638
Find similar

United Airlines flights from Detroit Metropolitan Wayne County Airport to Panama City

Our best United Airlines deals on Detroit Metropolitan Wayne County Airport to Panama City flight tickets
United Airlines
Mar 7
DTW6:06 pmDetroit Metropolitan Wayne County
11h 04m
2 stops
PTY5:10 amPanama City Tocumen Intl
Mar 17
PTY9:30 amPanama City Tocumen Intl
9h 47m
1 stop
DTW8:17 pmDetroit Metropolitan Wayne County
$643
Find similar
United Airlines
Mar 14
DTW6:49 pmDetroit Metropolitan Wayne County
10h 21m
1 stop
PTY4:10 amPanama City Tocumen Intl
Mar 22
PTY10:55 pmPanama City Tocumen Intl
10h 57m
1 stop
DTW10:52 amDetroit Metropolitan Wayne County
$659
Find similar
United Airlines
Mar 14
DTW2:15 pmDetroit Metropolitan Wayne County
14h 55m
2 stops
PTY4:10 amPanama City Tocumen Intl
Mar 22
PTY3:41 pmPanama City Tocumen Intl
20h 44m
2 stops
DTW1:25 pmDetroit Metropolitan Wayne County
$663
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 2/2

6:35 am-12:40 am

2 stops18h 05m

Panama City Tocumen Intl

Sun 2/8

9:45 am-10:12 pm

2 stops12h 27m

$516

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/21

6:35 am-12:40 am

2 stops18h 05m

Panama City Tocumen Intl

Mon 1/26

2:55 am-10:44 pm

2 stops19h 49m

$531

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 12/8

11:07 am-8:37 pm

1 stop9h 30m

Panama City Tocumen Intl

Wed 12/10

5:50 pm-3:34 pm

2 stops21h 44m

$539

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/17

5:35 am-1:40 pm

1 stop8h 05m

Panama City Tocumen Intl

Tue 3/3

2:52 pm-11:53 pm

1 stop9h 01m

$609

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/17

5:24 pm-1:40 pm

2 stops20h 16m

Panama City Tocumen Intl

Tue 3/3

2:52 pm-10:39 am

2 stops19h 47m

$613

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 3/6

5:35 am-3:14 pm

1 stop9h 39m

Panama City Tocumen Intl

Sun 3/15

3:50 pm-10:47 am

2 stops17h 57m

$638

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/7

6:06 pm-5:10 am

2 stops11h 04m

Panama City Tocumen Intl

Tue 3/17

9:30 am-8:17 pm

1 stop9h 47m

$643

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 3/6

5:35 am-3:14 pm

1 stop9h 39m

Panama City Tocumen Intl

Sun 3/15

1:50 pm-4:53 pm

1 stop26h 03m

$649

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/14

6:49 pm-4:10 am

1 stop10h 21m

Panama City Tocumen Intl

Sun 3/22

10:55 pm-10:52 am

1 stop10h 57m

$659

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/14

2:15 pm-4:10 am

2 stops14h 55m

Panama City Tocumen Intl

Sun 3/22

3:41 pm-1:25 pm

2 stops20h 44m

$663

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, June is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $723. If you’re not able to fly to Panama City in June, then October is your next best option. Flight prices from Detroit Metropolitan Wayne County Airport to Panama City during October average around $736.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $745. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $861. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Panama City during this time can be as low as $786. Try not to purchase tickets in the afternoon because they tend to be around $923. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Detroit Metropolitan Wayne County Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Panama City (DTW to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Panama City

Direct flights

None
There are no direct flights from Detroit Metropolitan Wayne County Airport to Panama City. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Panama City.
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Panama City Tocumen Intl by plane?

    A flight from Detroit Metropolitan Wayne County to Panama City Tocumen Intl will travel around 2306.7 mi. In terms of flight time, this usually takes a little over 7h 57m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Panama City?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Panama City

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
9,012 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
8,007 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Panama City with flexible booking policies on momondo?

Flights from Detroit to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Detroit.

I’m not ready to book a flight from Detroit to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Detroit and alert you when they change.

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