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Cheap flights from Detroit Metropolitan Wayne County Airport to Panama City from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Panama City departing on 10/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Panama City

Cheap round-trip flights

Multiple Airlines Logo
6:17 am - 12:40 amDTW-PTY
19h 23m2 stops
Multiple Airlines Logo
5:55 pm - 2:09 pmPTY-DTW
20h 14m2 stops
$408Multiple Airlines
Find Deal
Mon, Oct 27 - Tue, Nov 4
Multiple Airlines Logo
6:43 am - 1:00 amDTW-PTY
19h 17m2 stops
Multiple Airlines Logo
5:55 pm - 2:09 pmPTY-DTW
20h 14m2 stops
$417Multiple Airlines
Find Deal
Tue, Oct 28 - Tue, Nov 11
Multiple Airlines Logo
6:43 am - 12:40 amDTW-PTY
18h 57m2 stops
Multiple Airlines Logo
2:55 am - 11:30 pmPTY-DTW
20h 35m2 stops
$424Multiple Airlines
Find Deal
Mon, Oct 27 - Mon, Nov 3
Multiple Airlines Logo
7:58 am - 1:00 amDTW-PTY
17h 02m2 stops
Multiple Airlines Logo
2:55 am - 9:23 pmPTY-DTW
18h 28m2 stops
$435Multiple Airlines
Find Deal
Tue, Dec 2 - Fri, Dec 5
Multiple Airlines Logo
6:43 am - 9:10 pmDTW-PTY
15h 27m2 stops
Multiple Airlines Logo
2:55 am - 11:30 pmPTY-DTW
19h 35m2 stops
$436Multiple Airlines
Find Deal
Wed, Oct 22 - Tue, Oct 28
Multiple Airlines Logo
6:43 am - 1:00 amDTW-PTY
19h 17m2 stops
Multiple Airlines Logo
5:55 pm - 2:09 pmPTY-DTW
20h 14m2 stops
$438Multiple Airlines
Find Deal
Tue, Oct 28 - Fri, Nov 14
Multiple Airlines Logo
9:05 pm - 12:10 amDTW-PTY
28h 05m3 stops
Multiple Airlines Logo
5:55 pm - 11:30 pmPTY-DTW
28h 35m2 stops
$445Multiple Airlines
Find Deal
Wed, Oct 22 - Wed, Oct 29
Multiple Airlines Logo
6:43 am - 9:10 pmDTW-PTY
15h 27m2 stops
Multiple Airlines Logo
3:20 am - 11:30 pmPTY-DTW
19h 10m2 stops
$451Multiple Airlines
Find Deal
Tue, Oct 7 - Thu, Oct 9
Multiple Airlines Logo
6:43 am - 9:10 pmDTW-PTY
15h 27m2 stops
Multiple Airlines Logo
5:55 pm - 11:30 pmPTY-DTW
28h 35m2 stops
$456Multiple Airlines
Find Deal
Wed, Oct 22 - Mon, Oct 27
Multiple Airlines Logo
6:43 am - 9:10 pmDTW-PTY
15h 27m2 stops
Multiple Airlines Logo
2:55 am - 11:30 pmPTY-DTW
19h 35m2 stops
$463Multiple Airlines
Find Deal
Wed, Oct 22 - Sun, Oct 26

American Airlines flights from Detroit Metropolitan Wayne County Airport to Panama City

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Panama City flight tickets
American Airlines
Oct 9
DTW7:26 pmDetroit Metropolitan Wayne County
19h 37m
2 stops
PTY2:03 pmPanama City Tocumen Intl
Oct 16
PTY3:15 pmPanama City Tocumen Intl
20h 37m
2 stops
DTW12:52 pmDetroit Metropolitan Wayne County
$791
Find similar
American Airlines
Sep 28
DTW6:06 amDetroit Metropolitan Wayne County
9h 25m
1 stop
PTY2:31 pmPanama City Tocumen Intl
Sep 30
PTY1:45 pmPanama City Tocumen Intl
8h 13m
1 stop
DTW10:58 pmDetroit Metropolitan Wayne County
$1,353
Find similar
American Airlines
Sep 28
DTW6:06 amDetroit Metropolitan Wayne County
9h 25m
1 stop
PTY2:31 pmPanama City Tocumen Intl
Sep 30
PTY1:45 pmPanama City Tocumen Intl
21h 09m
2 stops
DTW11:54 amDetroit Metropolitan Wayne County
$1,358
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 10/27

6:17 am-12:40 am

2 stops19h 23m

Panama City Tocumen Intl

Tue 11/4

5:55 pm-2:09 pm

2 stops20h 14m

$408

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 10/28

6:43 am-1:00 am

2 stops19h 17m

Panama City Tocumen Intl

Tue 11/11

5:55 pm-2:09 pm

2 stops20h 14m

$417

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 10/27

6:43 am-12:40 am

2 stops18h 57m

Panama City Tocumen Intl

Mon 11/3

2:55 am-11:30 pm

2 stops20h 35m

$424

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 12/2

7:58 am-1:00 am

2 stops17h 02m

Panama City Tocumen Intl

Fri 12/5

2:55 am-9:23 pm

2 stops18h 28m

$435

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 10/22

6:43 am-9:10 pm

2 stops15h 27m

Panama City Tocumen Intl

Tue 10/28

2:55 am-11:30 pm

2 stops19h 35m

$436

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 10/28

6:43 am-1:00 am

2 stops19h 17m

Panama City Tocumen Intl

Fri 11/14

5:55 pm-2:09 pm

2 stops20h 14m

$438

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 10/22

9:05 pm-12:10 am

3 stops28h 05m

Panama City Tocumen Intl

Wed 10/29

5:55 pm-11:30 pm

2 stops28h 35m

$445

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 10/7

6:43 am-9:10 pm

2 stops15h 27m

Panama City Tocumen Intl

Thu 10/9

3:20 am-11:30 pm

2 stops19h 10m

$451

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 10/22

6:43 am-9:10 pm

2 stops15h 27m

Panama City Tocumen Intl

Mon 10/27

5:55 pm-11:30 pm

2 stops28h 35m

$456

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 10/22

6:43 am-9:10 pm

2 stops15h 27m

Panama City Tocumen Intl

Sun 10/26

2:55 am-11:30 pm

2 stops19h 35m

$463

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $730. If you’re not able to fly to Panama City in April, then June is your next best option. Flight prices from Detroit Metropolitan Wayne County Airport to Panama City during June average around $735.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $745. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $861. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Panama City during this time can be as low as $786. Try not to purchase tickets in the afternoon because they tend to be around $923. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $894 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Detroit Metropolitan Wayne County Airport for as low as $622 on momondo.

When to book flights from Detroit Metropolitan Wayne County Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Panama City (DTW to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Panama City

Direct flights

None
There are no direct flights from Detroit Metropolitan Wayne County Airport to Panama City. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Panama City.
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  • How far is Detroit Metropolitan Wayne County to Panama City Tocumen Intl by plane?

    A flight from Detroit Metropolitan Wayne County to Panama City Tocumen Intl will travel around 2306.7 mi. In terms of flight time, this usually takes a little over 8h 55m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Panama City?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Panama City

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
7,973 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Panama City with flexible booking policies on momondo?

Flights from Detroit to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Detroit.

I’m not ready to book a flight from Detroit to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Detroit and alert you when they change.

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