Cheap flights from Colorado to Panama City from $267

In general, April is the cheapest month to fly from Colorado to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $589. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from Colorado to Panama City during May average around $602.

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $538. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $627. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Fly from Denver Intl to Panama City Tocumen Intl for the best Colorado - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Colorado when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $667 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Colorado for as low as $572 on momondo.

There are 3 cabin classes available to choose from on Colorado to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 62% on your flight if you consider stops on a Colorado to Panama City flight.

American Airlines and Copa Airlines are the most popular carriers operating from Colorado to Panama City Tocumen Intl

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama City from Colorado according to our data. Copa Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

As of August 2026, there are 1 flights per day flying from Colorado to Panama City. The most common time of day flights depart is 10:00PM, with 100% of flights taking off in the evening.

As of August 2026, 12 flights take off from Colorado and land in Panama City each week. The most common flight departure day for this route is Mon, with 17% of weekly flights taking off on this day.