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Cheap flights from Chicago to Santa Cruz de la Sierra from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Santa Cruz de la Sierra departing on 2/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
10:20 pm - 2:35 am
ORD
-
VVI
26h 15m
1 stop
Avianca Logo
2:55 am - 9:20 pm
VVI
-
ORD
19h 25m
1 stop
$601Avianca
Mon, Feb 23 - Wed, Apr 1
Avianca Logo
11:20 pm - 1:50 am
ORD
-
VVI
25h 30m
1 stop
Avianca Logo
2:55 am - 9:20 pm
VVI
-
ORD
19h 25m
1 stop
$606Avianca
Fri, Apr 3 - Sun, Apr 12
Copa Airlines Logo
3:21 pm - 3:40 am
ORD
-
VVI
11h 19m
1 stop
Copa Airlines Logo
1:15 am - 1:58 pm
VVI
-
ORD
13h 43m
1 stop
$610Copa Airlines
Fri, Apr 3 - Sun, Apr 12
United Airlines Logo
9:28 pm - 10:42 pm
ORD
-
VVI
24h 14m
2 stops
United Airlines Logo
11:48 am - 7:26 am
VVI
-
ORD
20h 38m
2 stops
$625United Airlines
Fri, Apr 3 - Mon, Apr 13
Avianca Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
Avianca Logo
3:35 am - 9:20 pm
VVI
-
ORD
18h 45m
1 stop
$632Avianca
Sat, May 16 - Mon, May 18
United Airlines Logo
5:45 am - 10:50 pm
ORD
-
VVI
15h 05m
2 stops
United Airlines Logo
11:48 am - 7:26 am
VVI
-
ORD
20h 38m
2 stops
$639United Airlines
Mon, Feb 23 - Thu, Apr 2
Avianca Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
Avianca Logo
3:35 am - 9:20 pm
VVI
-
ORD
18h 45m
1 stop
$667Avianca
Fri, Apr 3 - Sun, Apr 12
Multiple Airlines Logo
8:50 am - 2:35 am
ORD
-
VVI
15h 45m
2 stops
Multiple Airlines Logo
3:35 am - 9:20 pm
VVI
-
ORD
18h 45m
1 stop
$672Multiple Airlines
Mon, Feb 23 - Wed, Apr 1
Avianca Logo
6:25 pm - 1:50 am
ORD
-
VVI
30h 25m
2 stops
Avianca Logo
2:55 am - 1:15 pm
VVI
-
ORD
11h 20m
1 stop
$676Avianca
Tue, Apr 7 - Mon, Apr 20
Multiple Airlines Logo
7:17 am - 2:35 am
ORD
-
VVI
18h 18m
2 stops
Multiple Airlines Logo
2:55 am - 11:17 pm
VVI
-
ORD
21h 22m
2 stops
$681Multiple Airlines
Wed, Mar 25 - Thu, Apr 9

Avianca flights from Chicago to Santa Cruz de la Sierra

Our best Avianca deals on Chicago to Santa Cruz de la Sierra flight tickets
Avianca
Feb 23
ORD10:20 pmChicago O'Hare Intl
26h 15m
1 stop
VVI2:35 amSanta Cruz de la Sierra Viru Viru Intl
Apr 1
VVI2:55 amSanta Cruz de la Sierra Viru Viru Intl
19h 25m
1 stop
ORD9:20 pmChicago O'Hare Intl
$601
Avianca
Apr 3
ORD11:20 pmChicago O'Hare Intl
25h 30m
1 stop
VVI1:50 amSanta Cruz de la Sierra Viru Viru Intl
Apr 12
VVI2:55 amSanta Cruz de la Sierra Viru Viru Intl
19h 25m
1 stop
ORD9:20 pmChicago O'Hare Intl
$606
Avianca
May 16
ORD11:20 pmChicago O'Hare Intl
26h 10m
1 stop
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
May 18
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
18h 45m
1 stop
ORD9:20 pmChicago O'Hare Intl
$632

Copa Airlines flights from Chicago to Santa Cruz de la Sierra

Our best Copa Airlines deals on Chicago to Santa Cruz de la Sierra flight tickets
Copa Airlines
Apr 3
ORD3:21 pmChicago O'Hare Intl
11h 19m
1 stop
VVI3:40 amSanta Cruz de la Sierra Viru Viru Intl
Apr 12
VVI1:15 amSanta Cruz de la Sierra Viru Viru Intl
13h 43m
1 stop
ORD1:58 pmChicago O'Hare Intl
$610
Copa Airlines
May 29
ORD8:02 amChicago O'Hare Intl
13h 36m
1 stop
VVI10:38 pmSanta Cruz de la Sierra Viru Viru Intl
Jun 5
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
13h 54m
1 stop
ORD2:06 pmChicago O'Hare Intl
$685
Copa Airlines
Feb 17
ORD7:34 amChicago O'Hare Intl
13h 16m
1 stop
VVI10:50 pmSanta Cruz de la Sierra Viru Viru Intl
Mar 2
VVI1:14 amSanta Cruz de la Sierra Viru Viru Intl
13h 17m
1 stop
ORD12:31 pmChicago O'Hare Intl
$742

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Chicago to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 2/23

10:20 pm-2:35 am

1 stop26h 15m

Santa Cruz de la Sierra Viru Viru Intl

Wed 4/1

2:55 am-9:20 pm

1 stop19h 25m

$601

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 4/3

11:20 pm-1:50 am

1 stop25h 30m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/12

2:55 am-9:20 pm

1 stop19h 25m

$606

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 4/3

3:21 pm-3:40 am

1 stop11h 19m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/12

1:15 am-1:58 pm

1 stop13h 43m

$610

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 4/3

9:28 pm-10:42 pm

2 stops24h 14m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/13

11:48 am-7:26 am

2 stops20h 38m

$625

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Sat 5/16

11:20 pm-2:30 am

1 stop26h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/18

3:35 am-9:20 pm

1 stop18h 45m

$632

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 2/23

5:45 am-10:50 pm

2 stops15h 05m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/2

11:48 am-7:26 am

2 stops20h 38m

$639

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 4/3

11:20 pm-2:30 am

1 stop26h 10m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/12

3:35 am-9:20 pm

1 stop18h 45m

$667

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 2/23

8:50 am-2:35 am

2 stops15h 45m

Santa Cruz de la Sierra Viru Viru Intl

Wed 4/1

3:35 am-9:20 pm

1 stop18h 45m

$672

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Tue 4/7

6:25 pm-1:50 am

2 stops30h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/20

2:55 am-1:15 pm

1 stop11h 20m

$676

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Wed 3/25

7:17 am-2:35 am

2 stops18h 18m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/9

2:55 am-11:17 pm

2 stops21h 22m

$681

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Chicago to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Chicago to Santa Cruz de la Sierra flights?

You could potentially save up to 20% on your flight if you consider stops on a Chicago to Santa Cruz de la Sierra flight.

When to book flights from Chicago to Santa Cruz de la Sierra

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Santa Cruz de la Sierra according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Santa Cruz de la Sierra (CHI to VVI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Santa Cruz de la Sierra

Fastest flight time

11h 19m

Direct flights

None
The fastest flight from Chicago to Santa Cruz de la Sierra takes 11h 19m
There are no direct flights from Chicago to Santa Cruz de la Sierra. There are no popular flight routes from Chicago to Santa Cruz de la Sierra.
Search flight deals

  • How far is Chicago to Santa Cruz de la Sierra Viru Viru Intl by plane?

    The straight-line distance from Chicago to Santa Cruz de la Sierra Viru Viru Intl is 4407.1 mi. 11h 19m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from Chicago to Santa Cruz de la Sierra Viru Viru Intl Airport were last updated today.

  • How many operators does momondo search for flights from Chicago to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from Chicago to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The travel and health documents required for your trip to Santa Cruz de la Sierra Viru Viru Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Cruz de la Sierra Viru Viru Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Chicago to Santa Cruz de la Sierra?

Best airlines flying from Chicago to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from Chicago to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $458Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Santa Cruz de la Sierra?

It is quick and easy to find Chicago to Santa Cruz de la Sierra flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santa Cruz de la Sierra that suits you.

Can I find flights from Chicago to Santa Cruz de la Sierra with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santa Cruz de la Sierra from Chicago with this policy.

How can momondo help me find flights from Chicago to Santa Cruz de la Sierra?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santa Cruz de la Sierra from Chicago.

I’m not ready to book a flight from Chicago to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Santa Cruz de la Sierra flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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