Twentyone Hotel

Via Cola Di Rienzo 23, 00192 Rome

+39 063 260 9607

per night


based on 2,112 reviews

Tue 5/18
Wed 5/19


Value for money

The Twentyone Hotel is a 4-star hotel close to the Piazza del Popolo in Rome, Italy. Part of the Vatican neighborhood, it is also close to the Via del Corso, Villa Borghese, and many other famous destinations in the historic city. Whether you are visiting for business or leisure, the central location makes it a convenient choice in accommodation. The Twentyone Hotel offers boutique-style amenities and services that include airport shuttles, 24-hour front desk service, and business services, along with meeting spaces. There is self-parking and private grounds to enjoy during a visit. There are also options for car hire, laundry, and dry cleaning, and a concierge, if needed. The 86 smoke-free rooms range in size from standard rooms to suites, and all rooms will provide you with a large and private bath, premium décor and linens, and free Wi-Fi. There is a sitting area, work desk, and minibar in every room. You also enjoy signature toiletries, an entertainment system, and options for room service. Bistro 21 is the signature restaurant in the hotel, and it specializes in Mediterranean cuisine served for all three meals. You can also head out into the neighborhood around the hotel and enjoy dining at MiVa, Astoria Café, Tacito, and many other establishments. When you book a stay at the Twentyone Hotel, you can walk to the Spanish Steps, the Piazza Navona, and the Castel Sant’Angelo. The Flaminio - Piazza del Popolo Station, Lepanto Station, and Rome S. Pietro Stations are all within half of an hour or less, and the Fiumicino - Leonardo da Vinci International Airport is less than 40 minutes by car.

Twentyone Hotel photos

Available rooms at Twentyone Hotel

Tue 5/18
Wed 5/19
Tue 5/18
Wed 5/19
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Standard Rooms - Courtyard view


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Double Rooms - Harbor view


$90 totalmomondo
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  • Restaurant
  • Bar/Lounge
  • Room service
  • Free Wi-Fi
  • Tea/coffee maker
  • Business center
  • Wi-Fi available in all areas
  • Flat-screen TV
  • TV
  • Cable or satellite TV

Health and safety

  • Daily housekeeping
  • Contactless check-in/check-out
  • Physical distancing in dining areas
  • Physical distancing rules
  • Property is cleaned by professional cleaning companies
  • Process in place to check health of guests
  • CCTV in common areas
  • Hand sanitizer in guest accommodation and key areas
  • Screens or physical barriers placed between staff and guests in appropriate areas
  • Use of cleaning chemicals that are effective against coronavirus
  • Guest accommodation is disinfected between stays
  • Guests can opt-out of accommodation cleaning
  • Staff follow all safety protocols as directed by local authorities
  • First-aid kit
  • Thermometers for guests provided by property
  • Safe
  • Cleaning products


  • Wi-Fi available in all areas
  • Internet
  • Fan
  • Fire extinguisher
  • Free toiletries
  • Smoke alarms
  • Heating
  • Air-conditioned
  • Free Wi-Fi
  • Linens
  • Towels
  • Shampoo
  • Adapter
  • Body soap
  • Trash cans
  • Conditioner

Accessibility and suitability

  • Entire unit wheelchair accessible
  • Multi-lingual staff
  • Hypoallergenic pillow
  • Lowered sink
  • Designated smoking area
  • Non-smoking rooms available
  • Increased accessibility
  • Roll-in shower
  • Elevator
  • Accessible by elevator
  • Allergy-free room
  • Toilet with grab rails
  • Upper floors accessible by elevator

Services and conveniences

  • Business center
  • Wake-up service
  • Concierge service
  • Meeting/Banquet facilities
  • Room service
  • Tour desk
  • Key card access
  • Express check-out
  • 24hr front desk
  • Smoking rooms available
  • Conference rooms
  • Ticket service
  • Safety deposit box


  • Hairdryer
  • Bathrobe
  • Private bathroom
  • Raised toilet
  • Shower
  • Shower cap
  • Bathtub
  • Bidet
  • Spa bath
  • Toilet
  • Toilet paper
  • Walk-in shower


  • Fruits
  • Restaurant
  • Bar/Lounge
  • Food can be delivered to guest accommodation
  • Minibar
  • Snack bar
  • Breakfast in the room
  • Tea/coffee maker
  • Refrigerator


  • Hardwood or parquet floors
  • Storage available
  • Seating area
  • Slippers
  • Sofa
  • Soundproof rooms
  • Soundproofing
  • Telephone
  • City view

Media and entertainment

  • Flat-screen TV
  • Cable or satellite TV
  • Pay-per-view channels
  • Streaming service
  • Shared lounge/TV area
  • TV


  • Laundry facilities
  • Ironing service
  • Laundry service
  • Pants press
  • Iron and ironing board

Parking and transportation

  • Parking
  • Airport shuttle (surcharge)
  • Private parking
  • Shuttle service (additional charge)


  • Outdoor furniture
  • Garden
  • Terrace/Patio
  • Balcony

Family friendly

  • Cribs available
  • Kids meals
  • Kid-friendly buffet
  • Children's television networks


  • Socket near the bed
  • Clothes rack


  • Fax/photocopying
  • Desk

Things to do

  • Bicycle rental
  • Beauty salon

Pool and spa

  • Hot tub

Places of interest near Twentyone Hotel

Recommendations carefully curated by Momondo Places


Piazza di Spagna0.7 mi
Piazza Navona0.7 mi
Spanish Steps0.7 mi
St. Peter's Square0.8 mi

Restaurants and Cafés

Bez Roma0.1 mi
DRAM0.3 mi
Locarno Bar0.3 mi
La Palapa0.4 mi

Traveler Reviews

GreatBased on 2112 verified guest reviews

Pros +
  • Excellent location and superb breakfast. (in 155 reviews)
  • Everything was excellent staff very helpful. (in 142 reviews)
  • Modern and clean rooms. (in 109 reviews)
Cons -
  • The room was too small. (in 59 reviews)
  • Horrible bed and eaven worse pillows! (in 33 reviews)
  • No tee or coffee in room. (in 14 reviews)

Traveler type:
Sort by:
3.7 Poor

Not very clean room Sheets not very clean and dusty Flies/insects inside the room Advertised as quiet room but noisy with thin walls (can hear everything outside and even played really loud music on first night which made me call them to tell them it was so loud so why did they advertise it as a quiet room???) Staff not smiling and not very warm No business center (not even a computer for accessing by clients)

9.7 Excellent
The atmosphere was great , trendy hallways and cool rooms.

Room was too hot

3.1 Poor

The room had a persistent mold/mildew smell that we could not get away from. The bathroom door would not stay open and was very heavy. Staff was made aware and they said they were booked for the night, but we could switch in the morning. We never heard back.

9.7 Excellent
Loved the rooms, the size, and the shower! So many rooms have terrible showers or shower pressure, this hotel was great in that regard
7.0 Good
Staff was friendly and helpful throughout the hotel and restaurant.

There was a strong oder of disinfectant throughout the hotel. You could feel the springs in the mattress.

1 out of 1

Info about your stay

Check in/Check out

Check in anytime after 2:00 PM, check out anytime before 11:00 AM


Cancellation/prepayment policies vary by room type and provider.

Frequently asked questions

  • 4 star hotels in Rome typically cost $174/night, but Twentyone Hotel is typically available for $104/night, and is rated equally to its competitors.

  • If you're looking to go directly from Rome Fiumicino to Twentyone Hotel, expect a 41min drive as they are around 13.7 mi apart.

  • With parking available at Twentyone Hotel, you could always rent a car for as low as $16/day and park it at the hotel. This would give you freedom while visiting Rome. If you’re looking for a simple travel option from Rome Fiumicino to Twentyone Hotel, consider calling a taxi or rideshare service to take you to the hotel as well as around the city during your visit.

  • Yes, Twentyone Hotel does have a restaurant where you can sit down to eat or take food to go. There are also many other quality food options in Rome for those looking for something different. Guests staying at Twentyone Hotel are welcomed by hotel staff to order room service directly from the kitchen to their room.

  • Unfortunately, our data does not specify if there is a pool at Twentyone Hotel. We would recommend calling the hotel’s front desk to confirm. The phone number for Twentyone Hotel is +39 063 260 9607.

  • The city center nearest to Twentyone Hotel is Rome, which is 1.3 mi away from the hotel’s front door. There, you can find Spanish Steps, which is a popular sight in the area.

  • The best contact number for Twentyone Hotel is +39 063 260 9607.

  • Yes, Twentyone Hotel has Wi-Fi available to hotel guests.

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