Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santiago to Panama City from $223

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Panama City departing on 3/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santiago to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
4:49 am - 10:35 am
SCL
-
PTY
6h 46mnonstop
Copa Airlines Logo
3:08 pm - 10:43 pm
PTY
-
SCL
6h 35mnonstop
$472Copa Airlines
Tue, Apr 21 - Wed, Apr 29
Copa Airlines Logo
4:49 am - 10:35 am
SCL
-
PTY
6h 46mnonstop
Copa Airlines Logo
9:35 pm - 5:10 am
PTY
-
SCL
6h 35mnonstop
$487Copa Airlines
Wed, Apr 8 - Wed, Apr 22
Avianca Logo
6:40 am - 2:15 pm
SCL
-
PTY
8h 35m
1 stop
Avianca Logo
10:10 am - 11:20 pm
PTY
-
SCL
12h 10m
1 stop
$503Avianca
Sun, May 24 - Sun, Jun 7
Avianca Logo
12:30 am - 5:00 pm
SCL
-
PTY
17h 30m
1 stop
Avianca Logo
3:05 am - 2:15 pm
PTY
-
SCL
10h 10m
1 stop
$504Avianca
Sat, May 23 - Sat, Jun 6
Avianca Logo
6:40 am - 2:15 pm
SCL
-
PTY
8h 35m
1 stop
Avianca Logo
3:05 am - 2:15 pm
PTY
-
SCL
10h 10m
1 stop
$516Avianca
Sun, May 24 - Sat, Jun 6
Avianca Logo
1:35 am - 8:50 am
SCL
-
PTY
9h 15m
1 stop
Avianca Logo
3:10 pm - 5:45 am
PTY
-
SCL
12h 35m
1 stop
$517Avianca
Sat, Mar 21 - Sun, Mar 29
Avianca Logo
1:35 am - 4:55 pm
SCL
-
PTY
17h 20m
1 stop
Avianca Logo
3:10 pm - 2:15 pm
PTY
-
SCL
22h 05m
1 stop
$520Avianca
Fri, Feb 20 - Thu, Apr 16
Copa Airlines Logo
4:17 am - 10:03 am
SCL
-
PTY
6h 46mnonstop
Copa Airlines Logo
3:51 pm - 11:26 pm
PTY
-
SCL
6h 35mnonstop
$521Copa Airlines
Sat, Apr 18 - Sat, May 2
Copa Airlines Logo
12:09 am - 5:55 am
SCL
-
PTY
6h 46mnonstop
Copa Airlines Logo
3:08 pm - 10:43 pm
PTY
-
SCL
6h 35mnonstop
$536Copa Airlines
Sun, Apr 19 - Sat, May 2
Copa Airlines Logo
5:21 am - 10:03 am
SCL
-
PTY
6h 42mnonstop
Copa Airlines Logo
3:18 pm - 11:49 pm
PTY
-
SCL
6h 31mnonstop
$541Copa Airlines
Sun, Mar 1 - Sat, Mar 7

Avianca flights from Santiago to Panama City

Our best Avianca deals on Santiago to Panama City flight tickets
Avianca
May 24
SCL6:40 amSantiago Arturo Merino Benitez
8h 35m
1 stop
PTY2:15 pmPanama City Tocumen Intl
Jun 7
PTY10:10 amPanama City Tocumen Intl
12h 10m
1 stop
SCL11:20 pmSantiago Arturo Merino Benitez
$503
Avianca
May 23
SCL12:30 amSantiago Arturo Merino Benitez
17h 30m
1 stop
PTY5:00 pmPanama City Tocumen Intl
Jun 6
PTY3:05 amPanama City Tocumen Intl
10h 10m
1 stop
SCL2:15 pmSantiago Arturo Merino Benitez
$504
Avianca
May 24
SCL6:40 amSantiago Arturo Merino Benitez
8h 35m
1 stop
PTY2:15 pmPanama City Tocumen Intl
Jun 6
PTY3:05 amPanama City Tocumen Intl
10h 10m
1 stop
SCL2:15 pmSantiago Arturo Merino Benitez
$516

Copa Airlines flights from Santiago to Panama City

Our best Copa Airlines deals on Santiago to Panama City flight tickets
Copa Airlines
Apr 20
SCL2:30 amSantiago Arturo Merino Benitez
6h 46m
PTY8:16 amPanama City Tocumen Intl
May 3
PTY11:48 amPanama City Tocumen Intl
6h 35m
SCL7:23 pmSantiago Arturo Merino Benitez
$472
Copa Airlines
Apr 8
SCL4:17 amSantiago Arturo Merino Benitez
6h 46m
PTY10:03 amPanama City Tocumen Intl
Apr 24
PTY6:45 pmPanama City Tocumen Intl
6h 35m
SCL2:20 amSantiago Arturo Merino Benitez
$487
Copa Airlines
Apr 18
SCL4:17 amSantiago Arturo Merino Benitez
6h 46m
PTY10:03 amPanama City Tocumen Intl
May 2
PTY3:08 pmPanama City Tocumen Intl
6h 35m
SCL10:43 pmSantiago Arturo Merino Benitez
$521

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 4/21

4:49 am-10:35 am

Nonstop6h 46m

Panama City Tocumen Intl

Wed 4/29

3:08 pm-10:43 pm

Nonstop6h 35m

$472

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 4/8

4:49 am-10:35 am

Nonstop6h 46m

Panama City Tocumen Intl

Wed 4/22

9:35 pm-5:10 am

Nonstop6h 35m

$487

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 5/24

6:40 am-2:15 pm

1 stop8h 35m

Panama City Tocumen Intl

Sun 6/7

10:10 am-11:20 pm

1 stop12h 10m

$503

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 5/23

12:30 am-5:00 pm

1 stop17h 30m

Panama City Tocumen Intl

Sat 6/6

3:05 am-2:15 pm

1 stop10h 10m

$504

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 5/24

6:40 am-2:15 pm

1 stop8h 35m

Panama City Tocumen Intl

Sat 6/6

3:05 am-2:15 pm

1 stop10h 10m

$516

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 3/21

1:35 am-8:50 am

1 stop9h 15m

Panama City Tocumen Intl

Sun 3/29

3:10 pm-5:45 am

1 stop12h 35m

$517

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 2/20

1:35 am-4:55 pm

1 stop17h 20m

Panama City Tocumen Intl

Thu 4/16

3:10 pm-2:15 pm

1 stop22h 05m

$520

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 4/18

4:17 am-10:03 am

Nonstop6h 46m

Panama City Tocumen Intl

Sat 5/2

3:51 pm-11:26 pm

Nonstop6h 35m

$521

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 4/19

12:09 am-5:55 am

Nonstop6h 46m

Panama City Tocumen Intl

Sat 5/2

3:08 pm-10:43 pm

Nonstop6h 35m

$536

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 3/1

5:21 am-10:03 am

Nonstop6h 42m

Panama City Tocumen Intl

Sat 3/7

3:18 pm-11:49 pm

Nonstop6h 31m

$541

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from Santiago to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Santiago to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $495. If you’re not able to fly to Panama City in November, then April is your next best option. Flight prices from Santiago to Panama City during April average around $529.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $527. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $627. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Santiago to Panama City during this time can be as low as $555. Try not to purchase tickets at noon because they tend to be around $596. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santiago Arturo Merino Benitez to Panama City Tocumen Intl flight route?

Fly from Santiago Arturo Merino Benitez to Panama City Tocumen Intl for the best Santiago Arturo Merino Benitez - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $553 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santiago for as low as $482 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Santiago Arturo Merino Benitez to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Panama City flights?

You could potentially save up to 57% on your flight if you consider stops on a Santiago to Panama City flight.

How have Santiago to Panama City flight prices changed over time?

As of February 2026, prices for Santiago to Panama City flights are approximately 38% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Panama City (SCL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Panama City

Best Price Found

$370

Fastest flight time

6h 43m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Santiago in the past 72 hours is $370. The best round-trip flight deal from Santiago to Panama City found on momondo in the last 72 hours is $502.
The fastest flight from Santiago to Panama City takes 6h 43m
Direct flights go from Santiago to Panama City every day.
There is 1 airport in Panama City. From Santiago there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Panama City Tocumen Intl by plane?

    There are 2987.0 mi between Santiago Arturo Merino Benitez and Panama City Tocumen Intl. 6h 43m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Panama City?

  • What is the most popular airline from Santiago to Panama City?

Best airlines flying from Santiago to Panama City

Compare and see reviews for airlines that fly from Santiago to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $450Free CancellationRating
7.5
1,556 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Santiago to Panama City

    Across 42 Copa Airlines flights from Santiago to Panama City this week, the average price was $598, with the best Copa Airlines deals starting from $450 round-trip. 1,556 users have rated Copa Airlines on momondo, with an average score of 7.5/10.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santiago to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santiago to Panama City with flexible booking policies on momondo?

Flights from Santiago to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santiago to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Santiago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santiago to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 3/10
Tue 3/17
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama