Cheap flights from Santiago to Panama City from $268

In general, November is the cheapest month to fly from Santiago to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $471. If you’re not able to fly to Panama City in November, then April is your next best option. Flight prices from Santiago to Panama City during April average around $532.

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $557. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $677. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Santiago to Panama City during this time can be as low as $590. Try not to purchase tickets in the morning because they tend to be around $600. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Santiago Arturo Merino Benitez to Panama City Tocumen Intl for the best Santiago Arturo Merino Benitez - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $560 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santiago for as low as $502 on momondo.

There are 3 cabin classes available to choose from on Santiago to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 57% on your flight if you consider stops on a Santiago to Panama City flight.

As of May 2026, prices for Santiago to Panama City flights are approximately 35% more expensive when compared to flights at the same time last year.

Historically, on average around 3% of flights between Santiago and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 100 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights at night have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Saturday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 3% of their flights experiencing any sort of delay.

The number of flights available between Santiago and Panama City is 11 per day as of May 2026. The most frequent departure time is 12:00AM, with 75% of daily flights leaving in the morning.

As of May 2026, 83 flights take off from Santiago and land in Panama City each week. The most common flight departure day for this route is Tue, with 16% of weekly flights taking off on this day.