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Cheap flights from Santiago to Panama City from $256

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Panama City departing on 12/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santiago to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
4:25 pm - 12:40 am
SCL
-
PTY
10h 15m1 stop
Avianca Logo
5:50 pm - 5:30 am
PTY
-
SCL
9h 40m1 stop
$538Avianca
Wed, Jan 21 - Wed, Jan 28
Avianca Logo
4:25 pm - 12:40 am
SCL
-
PTY
10h 15m1 stop
Avianca Logo
2:55 am - 3:20 pm
PTY
-
SCL
10h 25m1 stop
$540Avianca
Fri, Mar 6 - Sun, Mar 22
Copa Airlines Logo
5:20 am - 10:03 am
SCL
-
PTY
6h 43mnonstop
Copa Airlines Logo
3:08 pm - 11:43 pm
PTY
-
SCL
6h 35mnonstop
$550Copa Airlines
Fri, Jan 23 - Mon, Jan 26
Copa Airlines Logo
5:44 am - 10:35 am
SCL
-
PTY
6h 51mnonstop
Copa Airlines Logo
6:45 pm - 2:20 am
PTY
-
SCL
6h 35mnonstop
$565Copa Airlines
Fri, Mar 20 - Sun, Apr 5
Avianca Logo
4:25 pm - 12:40 am
SCL
-
PTY
10h 15m1 stop
Avianca Logo
9:45 am - 12:30 am
PTY
-
SCL
12h 45m1 stop
$567Avianca
Wed, Feb 11 - Tue, Feb 17
Copa Airlines Logo
5:20 am - 10:03 am
SCL
-
PTY
6h 43mnonstop
Copa Airlines Logo
6:45 pm - 3:17 am
PTY
-
SCL
6h 32mnonstop
$570Copa Airlines
Tue, Jan 20 - Tue, Jan 27
Avianca Logo
4:25 pm - 1:00 am
SCL
-
PTY
10h 35m1 stop
Avianca Logo
2:55 am - 3:20 pm
PTY
-
SCL
10h 25m1 stop
$573Avianca
Thu, Feb 12 - Wed, Feb 18
Copa Airlines Logo
12:25 pm - 5:11 pm
SCL
-
PTY
6h 46mnonstop
Copa Airlines Logo
3:08 pm - 10:43 pm
PTY
-
SCL
6h 35mnonstop
$580Copa Airlines
Wed, Apr 1 - Wed, Apr 8
Avianca Logo
1:35 am - 8:50 am
SCL
-
PTY
9h 15m1 stop
Avianca Logo
9:45 am - 12:30 am
PTY
-
SCL
12h 45m1 stop
$581Avianca
Sat, Feb 7 - Tue, Feb 17
Avianca Logo
1:35 am - 8:50 am
SCL
-
PTY
9h 15m1 stop
Avianca Logo
5:50 pm - 3:20 pm
PTY
-
SCL
19h 30m1 stop
$584Avianca
Sat, Feb 7 - Sun, Feb 22

Copa Airlines flights from Santiago to Panama City

Our best Copa Airlines deals on Santiago to Panama City flight tickets
Copa Airlines
Jan 23
SCL5:20 amSantiago Arturo Merino Benitez
6h 43m
PTY10:03 amPanama City Tocumen Intl
Jan 26
PTY3:08 pmPanama City Tocumen Intl
6h 35m
SCL11:43 pmSantiago Arturo Merino Benitez
$550
Find similar
Copa Airlines
Mar 20
SCL5:44 amSantiago Arturo Merino Benitez
6h 51m
PTY10:35 amPanama City Tocumen Intl
Apr 5
PTY6:45 pmPanama City Tocumen Intl
6h 35m
SCL2:20 amSantiago Arturo Merino Benitez
$565
Find similar
Copa Airlines
Jan 20
SCL12:28 pmSantiago Arturo Merino Benitez
6h 43m
PTY5:11 pmPanama City Tocumen Intl
Feb 10
PTY11:48 amPanama City Tocumen Intl
6h 32m
SCL8:20 pmSantiago Arturo Merino Benitez
$570
Find similar

Avianca flights from Santiago to Panama City

Our best Avianca deals on Santiago to Panama City flight tickets
Avianca
Jan 21
SCL4:25 pmSantiago Arturo Merino Benitez
10h 15m
1 stop
PTY12:40 amPanama City Tocumen Intl
Jan 28
PTY5:50 pmPanama City Tocumen Intl
9h 40m
1 stop
SCL5:30 amSantiago Arturo Merino Benitez
$538
Find similar
Avianca
Mar 6
SCL4:25 pmSantiago Arturo Merino Benitez
10h 15m
1 stop
PTY12:40 amPanama City Tocumen Intl
Mar 22
PTY2:55 amPanama City Tocumen Intl
10h 25m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
$540
Find similar
Avianca
Feb 11
SCL4:25 pmSantiago Arturo Merino Benitez
10h 15m
1 stop
PTY12:40 amPanama City Tocumen Intl
Feb 17
PTY9:45 amPanama City Tocumen Intl
12h 45m
1 stop
SCL12:30 amSantiago Arturo Merino Benitez
$567
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 25, 2025.
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 1/21

4:25 pm-12:40 am

1 stop10h 15m

Panama City Tocumen Intl

Wed 1/28

5:50 pm-5:30 am

1 stop9h 40m

$538

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 3/6

4:25 pm-12:40 am

1 stop10h 15m

Panama City Tocumen Intl

Sun 3/22

2:55 am-3:20 pm

1 stop10h 25m

$540

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 1/23

5:20 am-10:03 am

Nonstop6h 43m

Panama City Tocumen Intl

Mon 1/26

3:08 pm-11:43 pm

Nonstop6h 35m

$550

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 3/20

5:44 am-10:35 am

Nonstop6h 51m

Panama City Tocumen Intl

Sun 4/5

6:45 pm-2:20 am

Nonstop6h 35m

$565

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 2/11

4:25 pm-12:40 am

1 stop10h 15m

Panama City Tocumen Intl

Tue 2/17

9:45 am-12:30 am

1 stop12h 45m

$567

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 1/20

5:20 am-10:03 am

Nonstop6h 43m

Panama City Tocumen Intl

Tue 1/27

6:45 pm-3:17 am

Nonstop6h 32m

$570

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Thu 2/12

4:25 pm-1:00 am

1 stop10h 35m

Panama City Tocumen Intl

Wed 2/18

2:55 am-3:20 pm

1 stop10h 25m

$573

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 4/1

12:25 pm-5:11 pm

Nonstop6h 46m

Panama City Tocumen Intl

Wed 4/8

3:08 pm-10:43 pm

Nonstop6h 35m

$580

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 2/7

1:35 am-8:50 am

1 stop9h 15m

Panama City Tocumen Intl

Tue 2/17

9:45 am-12:30 am

1 stop12h 45m

$581

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 2/7

1:35 am-8:50 am

1 stop9h 15m

Panama City Tocumen Intl

Sun 2/22

5:50 pm-3:20 pm

1 stop19h 30m

$584

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Santiago to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Santiago to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $494. If you’re not able to fly to Panama City in November, then October is your next best option. Flight prices from Santiago to Panama City during October average around $518.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $539. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $630. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Santiago to Panama City during this time can be as low as $416. Try not to purchase tickets at noon because they tend to be around $596. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santiago Arturo Merino Benitez to Panama City Tocumen Intl flight route?

Fly from Santiago Arturo Merino Benitez to Panama City Tocumen Intl for the best Santiago Arturo Merino Benitez - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $549 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santiago for as low as $486 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Santiago Arturo Merino Benitez to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Panama City flights?

You could potentially save up to 60% on your flight if you consider stops on a Santiago to Panama City flight.

How have Santiago to Panama City flight prices changed over time?

As of December 2025, prices for Santiago to Panama City flights are approximately 23% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Panama City (SCL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Panama City

Best Price Found

$270

Fastest flight time

6h 43m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Santiago in the past 72 hours is $270. The best round-trip flight deal from Santiago to Panama City found on momondo in the last 72 hours is $432.
The fastest flight from Santiago to Panama City takes 6h 43m
Direct flights go from Santiago to Panama City every day.
There is 1 airport in Panama City. From Santiago there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Panama City Tocumen Intl by plane?

    There are 2987.0 mi between Santiago Arturo Merino Benitez and Panama City Tocumen Intl. 6h 43m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Panama City?

  • What is the most popular airline from Santiago to Panama City?

Best airlines flying from Santiago to Panama City

Compare and see reviews for airlines that fly from Santiago to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $450Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
AviancaPriceFrom $468Free CancellationRating
6.6
2,490 reviews
Search Avianca flights

  • Copa Airlines Flights From Santiago to Panama City

    Across 37 Copa Airlines flights from Santiago to Panama City this week, the average price was $600, with the best Copa Airlines deals starting from $450 round-trip. 1,559 users have rated Copa Airlines on momondo, with an average score of 7.6/10.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santiago to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santiago to Panama City with flexible booking policies on momondo?

Flights from Santiago to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santiago to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Santiago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santiago to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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