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Cheap flights from Missouri to Panama City from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 1/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:44 am - 12:58 pmMCI  Kansas City-PTY Panama City Tocumen Intl
7h 14m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:24 pm - 11:56 pmPTY  Panama City Tocumen Intl-MCI Kansas City
9h 32m1 stop Atlanta Hartsfield-Jackson
$577Delta
Wed, Sep 23 - Wed, Oct 7
United Airlines Logo
6:39 pm - 2:14 pmMCI  Kansas City-PTY Panama City Tocumen Intl
19h 35m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
3:30 pm - 2:18 pmPTY  Panama City Tocumen Intl-MCI Kansas City
22h 48m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$581United Airlines
Mon, Sep 28 - Wed, Sep 30
American Airlines Logo
12:19 pm - 12:16 pmMCI  Kansas City-PTY Panama City Tocumen Intl
23h 57m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
2:02 pm - 8:57 amPTY  Panama City Tocumen Intl-MCI Kansas City
18h 55m2 stops Miami Dallas/Fort Worth
$586American Airlines
Wed, Sep 23 - Wed, Oct 7
American Airlines Logo
3:38 pm - 1:27 pmMCI  Kansas City-PTY Panama City Tocumen Intl
20h 49m2 stops Washington, D.C. Reagan-National Miami
American Airlines Logo
4:46 pm - 11:05 amPTY  Panama City Tocumen Intl-MCI Kansas City
19h 19m2 stops Miami Dallas/Fort Worth
$586American Airlines
Wed, Jan 13 - Wed, Jan 27
United Airlines Logo
6:39 pm - 2:14 pmMCI  Kansas City-PTY Panama City Tocumen Intl
19h 35m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
3:30 pm - 10:06 amPTY  Panama City Tocumen Intl-MCI Kansas City
18h 36m1 stop Houston George Bush Intcntl
$591United Airlines
Mon, Sep 28 - Wed, Sep 30
Delta Logo
6:42 pm - 1:55 pmMCI  Kansas City-PTY Panama City Tocumen Intl
18h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:20 pm - 10:26 pmPTY  Panama City Tocumen Intl-MCI Kansas City
8h 06m1 stop Atlanta Hartsfield-Jackson
$597Delta
Sun, Jan 24 - Wed, Feb 3
Multiple Airlines Logo
8:22 am - 1:55 amMCI  Kansas City-PTY Panama City Tocumen Intl
17h 33m2 stops Houston George Bush Intcntl San Salvador El Salvador Intl
Multiple Airlines Logo
5:30 am - 10:35 pmPTY  Panama City Tocumen Intl-MCI Kansas City
17h 05m2 stops San Salvador El Salvador Intl Houston George Bush Intcntl
$648Multiple Airlines
Sat, Oct 10 - Sat, Oct 17
Multiple Airlines Logo
12:10 pm - 1:55 amMCI  Kansas City-PTY Panama City Tocumen Intl
13h 45m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl
Multiple Airlines Logo
5:30 am - 10:35 pmPTY  Panama City Tocumen Intl-MCI Kansas City
17h 05m2 stops San Salvador El Salvador Intl Houston George Bush Intcntl
$696Multiple Airlines
Sun, Sep 6 - Sun, Sep 13
Copa Airlines Logo
6:15 am - 2:45 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 30m1 stop Houston George Bush Intcntl
Copa Airlines Logo
8:55 am - 4:44 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
8h 49m1 stop Houston George Bush Intcntl
$729Copa Airlines
Sun, Jan 24 - Sat, Feb 6
Copa Airlines Logo
6:15 am - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
9h 57m1 stop Houston George Bush Intcntl
Copa Airlines Logo
4:41 pm - 10:06 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 25m1 stop Houston George Bush Intcntl
$739Copa Airlines
Sat, Jan 9 - Sun, Jan 17

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Delta flights from Missouri to Panama City

Our best Delta deals on Missouri to Panama City flight tickets
Delta
Sep 23
MCI5:44 amKansas City
7h 14m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Oct 7
PTY2:24 pmPanama City Tocumen Intl
9h 32m
1 stop
MCI11:56 pmKansas City
$577
Delta
Jan 24
MCI6:42 pmKansas City
18h 13m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Feb 8
PTY3:20 pmPanama City Tocumen Intl
26h 06m
1 stop
MCI4:26 pmKansas City
$607
Delta
Sep 15
MCI5:44 amKansas City
7h 14m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 22
PTY2:23 pmPanama City Tocumen Intl
9h 28m
1 stop
MCI11:51 pmKansas City
$667

American Airlines flights from Missouri to Panama City

Our best American Airlines deals on Missouri to Panama City flight tickets
American Airlines
Sep 23
MCI12:19 pmKansas City
23h 57m
2 stops
PTY12:16 pmPanama City Tocumen Intl
Oct 7
PTY2:02 pmPanama City Tocumen Intl
18h 55m
2 stops
MCI8:57 amKansas City
$586
American Airlines
Jan 13
MCI11:40 amKansas City
26h 58m
1 stop
PTY3:38 pmPanama City Tocumen Intl
Jan 27
PTY4:46 pmPanama City Tocumen Intl
19h 19m
2 stops
MCI11:05 amKansas City
$600
American Airlines
Jan 13
MCI3:38 pmKansas City
20h 49m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Jan 27
PTY4:46 pmPanama City Tocumen Intl
19h 19m
2 stops
MCI11:05 amKansas City
$606

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Wed 9/23

5:44 am-12:58 pm

1 stop7h 14m

Panama City Tocumen Intl

Wed 10/7

2:24 pm-11:56 pm

1 stop9h 32m

$577

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Mon 9/28

6:39 pm-2:14 pm

2 stops19h 35m

Panama City Tocumen Intl

Wed 9/30

3:30 pm-2:18 pm

2 stops22h 48m

$581

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Wed 9/23

12:19 pm-12:16 pm

2 stops23h 57m

Panama City Tocumen Intl

Wed 10/7

2:02 pm-8:57 am

2 stops18h 55m

$586

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Wed 1/13

3:38 pm-1:27 pm

2 stops20h 49m

Panama City Tocumen Intl

Wed 1/27

4:46 pm-11:05 am

2 stops19h 19m

$586

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Mon 9/28

6:39 pm-2:14 pm

2 stops19h 35m

Panama City Tocumen Intl

Wed 9/30

3:30 pm-10:06 am

1 stop18h 36m

$591

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Sun 1/24

6:42 pm-1:55 pm

1 stop18h 13m

Panama City Tocumen Intl

Wed 2/3

3:20 pm-10:26 pm

1 stop8h 06m

$597

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Sat 10/10

8:22 am-1:55 am

2 stops17h 33m

Panama City Tocumen Intl

Sat 10/17

5:30 am-10:35 pm

2 stops17h 05m

$648

Kansas CityPanama City

MCI Kansas City - PTY Panama City Tocumen Intl

MCIPTY

Kansas City

Sun 9/6

12:10 pm-1:55 am

2 stops13h 45m

Panama City Tocumen Intl

Sun 9/13

5:30 am-10:35 pm

2 stops17h 05m

$696
Quickest round-trip

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Sun 1/24

6:15 am-2:45 pm

1 stop7h 30m

Panama City Tocumen Intl

Sat 2/6

8:55 am-4:44 pm

1 stop8h 49m

$729

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Sat 1/9

6:15 am-5:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Sun 1/17

4:41 pm-10:06 pm

1 stop30h 25m

$739

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Missouri to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Missouri to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $522. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from Missouri to Panama City during November average around $529.

Can stopping save me money on Missouri to Panama City flights?

You could potentially save up to 21% on your flight if you consider stops on a Missouri to Panama City flight.

Cheap Missouri to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City

Fastest flight time

7h 14m

Direct flights

None
The fastest flight from Missouri to Panama City takes 7h 14m
There are no direct flights from Missouri to Panama City. There are no popular flight routes from Missouri to Panama City.
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Frequently asked questions about flying from Missouri to Panama City

  • When did momondo last update prices for flights from Missouri to Panama City Tocumen Intl Airport?

    Prices for flights from Missouri to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Missouri to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama City

Compare and see reviews for airlines that fly from Missouri to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,892 reviews
Search American Airlines flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
10,089 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $446Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
DeltaPriceFrom $461Free CancellationRating
7.8
8,496 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Missouri.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama City?

Once all potential Missouri to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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