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Cheap flights from Missouri to Panama City from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Delta Logo
6:00 am - 12:50 pmSTL-PTY
6h 50m1 stop
Delta Logo
2:10 pm - 10:00 pmPTY-STL
7h 50m1 stop
$393Delta
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Tue, Sep 9 - Tue, Sep 16
United Airlines Logo
6:15 am - 5:07 pmSTL-PTY
9h 52m1 stop
United Airlines Logo
4:40 pm - 2:18 pmPTY-STL
22h 38m2 stops
$398United Airlines
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Thu, Jan 22 - Mon, Jan 26
United Airlines Logo
8:10 am - 6:37 pmMCI-PTY
10h 27m1 stop
United Airlines Logo
3:41 pm - 9:29 amPTY-MCI
17h 48m1 stop
$408United Airlines
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Thu, Oct 16 - Thu, Oct 30
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 9:57 amPTY-STL
18h 27m1 stop
$410United Airlines
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Mon, Sep 15 - Sat, Sep 20
American Airlines Logo
3:50 pm - 2:31 pmMCI-PTY
22h 41m2 stops
American Airlines Logo
3:31 pm - 11:59 pmPTY-MCI
8h 28m1 stop
$428American Airlines
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Thu, Sep 25 - Thu, Oct 2
American Airlines Logo
5:28 am - 2:31 pmSTL-PTY
9h 03m1 stop
American Airlines Logo
3:31 pm - 11:59 pmPTY-STL
8h 28m1 stop
$437American Airlines
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Fri, Sep 26 - Fri, Oct 3
Logo
5:15 am - 12:10 amMCI-PTY
18h 55m3 stops
Logo
5:25 pm - 11:07 pmPTY-MCI
29h 42m3 stops
$565
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Tue, Sep 9 - Tue, Sep 16
Logo
5:15 am - 12:10 amMCI-PTY
18h 55m2 stops
Logo
3:20 am - 11:07 pmPTY-MCI
19h 47m2 stops
$576
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Thu, Sep 4 - Sun, Sep 7
Avianca Logo
8:15 am - 12:10 amSTL-PTY
15h 55m2 stops
Avianca Logo
1:30 pm - 10:02 amPTY-STL
20h 32m3 stops
$1,480Avianca
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Sat, Sep 13 - Sat, Sep 20
Avianca Logo
8:15 am - 4:30 pmSTL-PTY
32h 15m2 stops
Avianca Logo
3:25 am - 10:02 amPTY-STL
30h 37m2 stops
$1,531Avianca
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Sat, Sep 13 - Fri, Sep 19

Delta flights from Missouri to Panama City

Our best Delta deals on Missouri to Panama City flight tickets
Delta
Sep 9
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
Sep 16
PTY2:10 pmPanama City Tocumen Intl
7h 50m
1 stop
STL10:00 pmLambert-St Louis
$393
Find similar
Delta
Nov 29
STL10:51 amLambert-St Louis
8h 10m
1 stop
PTY8:01 pmPanama City Tocumen Intl
Dec 6
PTY8:05 amPanama City Tocumen Intl
10h 57m
1 stop
STL6:02 pmLambert-St Louis
$427
Find similar
Delta
Sep 9
MCI5:45 amKansas City
7h 05m
1 stop
PTY12:50 pmPanama City Tocumen Intl
Sep 16
PTY2:10 pmPanama City Tocumen Intl
9h 34m
1 stop
MCI11:44 pmKansas City
$437
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United Airlines flights from Missouri to Panama City

Our best United Airlines deals on Missouri to Panama City flight tickets
United Airlines
Jan 22
STL6:15 amLambert-St Louis
9h 52m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Jan 26
PTY4:40 pmPanama City Tocumen Intl
22h 38m
2 stops
STL2:18 pmLambert-St Louis
$398
Find similar
United Airlines
Oct 16
MCI8:10 amKansas City
10h 27m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 30
PTY3:41 pmPanama City Tocumen Intl
17h 48m
1 stop
MCI9:29 amKansas City
$408
Find similar
United Airlines
Sep 15
STL6:15 amLambert-St Louis
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Sep 20
PTY3:30 pmPanama City Tocumen Intl
18h 27m
1 stop
STL9:57 amLambert-St Louis
$410
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-10:00 pm

1 stop7h 50m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 1/22

6:15 am-5:07 pm

1 stop9h 52m

Panama City Tocumen Intl

Mon 1/26

4:40 pm-2:18 pm

2 stops22h 38m

$398

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 10/16

8:10 am-6:37 pm

1 stop10h 27m

Panama City Tocumen Intl

Thu 10/30

3:41 pm-9:29 am

1 stop17h 48m

$408

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 9/15

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Sat 9/20

3:30 pm-9:57 am

1 stop18h 27m

$410

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 9/25

3:50 pm-2:31 pm

2 stops22h 41m

Panama City Tocumen Intl

Thu 10/2

3:31 pm-11:59 pm

1 stop8h 28m

$428

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/26

5:28 am-2:31 pm

1 stop9h 03m

Panama City Tocumen Intl

Fri 10/3

3:31 pm-11:59 pm

1 stop8h 28m

$437

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 9/9

5:15 am-12:10 am

3 stops18h 55m

Panama City Tocumen Intl

Tue 9/16

5:25 pm-11:07 pm

3 stops29h 42m

$565

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 9/4

5:15 am-12:10 am

2 stops18h 55m

Panama City Tocumen Intl

Sun 9/7

3:20 am-11:07 pm

2 stops19h 47m

$576

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 9/13

8:15 am-12:10 am

2 stops15h 55m

Panama City Tocumen Intl

Sat 9/20

1:30 pm-10:02 am

3 stops20h 32m

$1,480

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 9/13

8:15 am-4:30 pm

2 stops32h 15m

Panama City Tocumen Intl

Fri 9/19

3:25 am-10:02 am

2 stops30h 37m

$1,531

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Missouri to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Missouri to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in April, then October is your next best option. Flight prices from Missouri to Panama City during October average around $479.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $509. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Missouri to Panama City during this time can be as low as $512. Try not to purchase tickets in the evening because they tend to be around $691. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $550 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Missouri for as low as $451 on momondo.

Can stopping save me money on Missouri to Panama City flights?

You could potentially save up to 39% on your flight if you consider stops on a Missouri to Panama City flight.

Cheap Missouri to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City

Best Price Found

$164

Fastest flight time

6h 50m

Direct flights

None

Airports in Panama City

1 airport
The best one-way flight to Panama City from Missouri in the past 72 hours is $164. The best round-trip flight deal from Missouri to Panama City found on momondo in the last 72 hours is $393.
The fastest flight from Missouri to Panama City takes 6h 50m
There are no direct flights from Missouri to Panama City. Popular non-direct routes for this connection are Springfield-Branson Airport - Panama City Tocumen Intl Airport, Lambert-St Louis Airport - Panama City Tocumen Intl Airport and Kansas City Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
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  • When did momondo last update prices for flights from Missouri to Panama City Tocumen Intl Airport?

    Prices for flights from Missouri to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Missouri to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama City

Compare and see reviews for airlines that fly from Missouri to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
8.0
7,979 reviews
Search Delta flights
United AirlinesPriceFrom $397Free CancellationRating
7.4
8,920 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Missouri.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama City?

Once all potential Missouri to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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