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Cheap flights from Missouri to Panama City from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 3/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:10 am - 7:38 pmSTL-PTY
8h 28m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-STL
17h 42m1 stop
$394United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:00 am - 7:38 pmSTL-PTY
12h 38m1 stop
United Airlines Logo
8:55 am - 10:00 pmPTY-STL
14h 05m2 stops
$398United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
American Airlines Logo
6:02 pm - 1:27 pmSTL-PTY
18h 25m1 stop
American Airlines Logo
4:50 pm - 9:08 amPTY-STL
17h 18m1 stop
$403American Airlines
Find Deal
Mon, Jan 19 - Fri, Jan 23
Delta Logo
6:42 pm - 12:55 pmMCI-PTY
18h 13m1 stop
Delta Logo
2:20 pm - 11:55 pmPTY-MCI
9h 35m1 stop
$409Delta
Find Deal
Mon, Apr 13 - Thu, Apr 16
United Airlines Logo
6:00 am - 5:07 pmSTL-PTY
10h 07m1 stop
United Airlines Logo
4:41 pm - 9:22 amPTY-STL
17h 41m1 stop
$411United Airlines
Find Deal
Fri, Jan 23 - Tue, Jan 27
United Airlines Logo
6:00 am - 6:37 pmMCI-PTY
12h 37m2 stops
United Airlines Logo
10:00 am - 8:51 amPTY-MCI
22h 51m2 stops
$413United Airlines
Find Deal
Mon, Apr 13 - Thu, Apr 16
American Airlines Logo
7:03 pm - 12:15 pmSTL-PTY
17h 12m2 stops
American Airlines Logo
1:55 pm - 9:35 pmPTY-STL
7h 40m1 stop
$415American Airlines
Find Deal
Fri, Apr 10 - Fri, Apr 17
Delta Logo
5:50 am - 2:12 pmMCI-PTY
7h 22m1 stop
Delta Logo
3:37 pm - 10:35 pmPTY-MCI
7h 58m1 stop
$612Delta
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Wed, Nov 19 - Wed, Nov 26
Multiple Airlines Logo
10:42 am - 8:34 pmSTL-PTY
8h 52m1 stop
Multiple Airlines Logo
2:55 am - 7:50 amPTY-STL
29h 55m2 stops
$744Multiple Airlines
Find Deal
Sun, Jan 18 - Sat, Jan 24
Multiple Airlines Logo
11:08 am - 8:19 pmSTL-PTY
8h 11m1 stop
Multiple Airlines Logo
2:55 am - 10:33 pmPTY-STL
20h 38m2 stops
$848Multiple Airlines
Find Deal
Sun, Nov 30 - Sat, Dec 6

American Airlines flights from Missouri to Panama City

Our best American Airlines deals on Missouri to Panama City flight tickets
American Airlines
Jan 19
STL6:02 pmLambert-St Louis
18h 25m
1 stop
PTY1:27 pmPanama City Tocumen Intl
Jan 23
PTY4:50 pmPanama City Tocumen Intl
17h 18m
1 stop
STL9:08 amLambert-St Louis
$403
Find similar
American Airlines
Apr 10
STL7:03 pmLambert-St Louis
17h 12m
2 stops
PTY12:15 pmPanama City Tocumen Intl
Apr 17
PTY1:55 pmPanama City Tocumen Intl
7h 40m
1 stop
STL9:35 pmLambert-St Louis
$415
Find similar
American Airlines
Feb 9
MCI11:42 amKansas City
24h 45m
1 stop
PTY1:27 pmPanama City Tocumen Intl
Feb 12
PTY2:52 pmPanama City Tocumen Intl
10h 05m
1 stop
MCI11:57 pmKansas City
$419
Find similar

United Airlines flights from Missouri to Panama City

Our best United Airlines deals on Missouri to Panama City flight tickets
United Airlines
Feb 17
STL10:10 amLambert-St Louis
8h 28m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 25
PTY4:41 pmPanama City Tocumen Intl
17h 42m
1 stop
STL9:23 amLambert-St Louis
$394
Find similar
United Airlines
Feb 17
STL6:00 amLambert-St Louis
12h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 25
PTY8:55 amPanama City Tocumen Intl
14h 05m
2 stops
STL10:00 pmLambert-St Louis
$398
Find similar
United Airlines
Jan 23
STL6:00 amLambert-St Louis
10h 07m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Jan 27
PTY4:41 pmPanama City Tocumen Intl
17h 41m
1 stop
STL9:22 amLambert-St Louis
$411
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

10:10 am-7:38 pm

1 stop8h 28m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

8:55 am-10:00 pm

2 stops14h 05m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 1/19

6:02 pm-1:27 pm

1 stop18h 25m

Panama City Tocumen Intl

Fri 1/23

4:50 pm-9:08 am

1 stop17h 18m

$403

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 4/13

6:42 pm-12:55 pm

1 stop18h 13m

Panama City Tocumen Intl

Thu 4/16

2:20 pm-11:55 pm

1 stop9h 35m

$409

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-9:22 am

1 stop17h 41m

$411

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 4/13

6:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Thu 4/16

10:00 am-8:51 am

2 stops22h 51m

$413

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

Fri 4/17

1:55 pm-9:35 pm

1 stop7h 40m

$415

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 11/19

5:50 am-2:12 pm

1 stop7h 22m

Panama City Tocumen Intl

Wed 11/26

3:37 pm-10:35 pm

1 stop7h 58m

$612

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 1/18

10:42 am-8:34 pm

1 stop8h 52m

Panama City Tocumen Intl

Sat 1/24

2:55 am-7:50 am

2 stops29h 55m

$744

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/30

11:08 am-8:19 pm

1 stop8h 11m

Panama City Tocumen Intl

Sat 12/6

2:55 am-10:33 pm

2 stops20h 38m

$848

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Missouri to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Missouri to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from Missouri to Panama City during May average around $504.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $509. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Missouri to Panama City during this time can be as low as $512. Try not to purchase tickets in the evening because they tend to be around $691. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $548 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Missouri for as low as $410 on momondo.

Can stopping save me money on Missouri to Panama City flights?

You could potentially save up to 39% on your flight if you consider stops on a Missouri to Panama City flight.

Cheap Missouri to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City

Direct flights

None
There are no direct flights from Missouri to Panama City. There are no popular flight routes from Missouri to Panama City.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama City Tocumen Intl Airport?

    Prices for flights from Missouri to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Missouri to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama City

Compare and see reviews for airlines that fly from Missouri to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $394Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Missouri.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama City?

Once all potential Missouri to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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