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Cheap flights from Missouri to Panama City from $181

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 5/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:15 pm - 4:12 pm
MCI
-
PTY
22h 57m
2 stops
United Airlines Logo
7:55 am - 4:42 pm
PTY
-
MCI
8h 47m
1 stop
$431United Airlines
Sun, May 10 - Wed, May 20
Copa Airlines Logo
3:16 pm - 4:04 am
MCI
-
PTY
12h 48m
2 stops
Copa Airlines Logo
3:30 pm - 10:21 am
PTY
-
MCI
18h 51m
2 stops
$433Copa Airlines
Tue, Aug 4 - Tue, Aug 18
United Airlines Logo
2:59 pm - 2:14 pm
MCI
-
PTY
23h 15m
1 stop
United Airlines Logo
7:55 am - 4:42 pm
PTY
-
MCI
8h 47m
1 stop
$435United Airlines
Sun, May 10 - Wed, May 20
Copa Airlines Logo
6:00 am - 4:04 am
MCI
-
PTY
22h 04m
1 stop
Copa Airlines Logo
3:30 pm - 10:03 am
PTY
-
MCI
18h 33m
1 stop
$438Copa Airlines
Thu, Jul 23 - Mon, Jul 27
United Airlines Logo
8:30 am - 2:14 pm
MCI
-
PTY
29h 44m
1 stop
United Airlines Logo
3:30 pm - 10:21 am
PTY
-
MCI
18h 51m
2 stops
$439United Airlines
Sun, Aug 2 - Mon, Aug 10
Copa Airlines Logo
6:00 am - 6:37 pm
MCI
-
PTY
12h 37m
2 stops
Copa Airlines Logo
3:30 pm - 10:05 am
PTY
-
MCI
18h 35m
1 stop
$441Copa Airlines
Tue, Aug 4 - Tue, Aug 18
United Airlines Logo
10:09 am - 6:37 pm
STL
-
PTY
8h 28m
1 stop
United Airlines Logo
10:00 am - 10:28 pm
PTY
-
STL
12h 28m
1 stop
$445United Airlines
Tue, Apr 7 - Thu, Apr 9
American Airlines Logo
6:20 pm - 3:01 pm
STL
-
PTY
20h 41m
1 stop
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
$455American Airlines
Wed, Apr 1 - Wed, Apr 8
American Airlines Logo
6:54 pm - 12:46 pm
STL
-
PTY
17h 52m
2 stops
American Airlines Logo
1:49 pm - 11:09 am
PTY
-
STL
21h 20m
2 stops
$471American Airlines
Thu, May 14 - Sun, May 17
Delta Logo
6:00 am - 1:02 pm
STL
-
PTY
7h 02m
1 stop
Delta Logo
2:27 pm - 11:36 pm
PTY
-
STL
9h 09m
1 stop
$479Delta
Sat, Apr 25 - Sat, May 2

American Airlines flights from Missouri to Panama City

Our best American Airlines deals on Missouri to Panama City flight tickets
American Airlines
Apr 1
STL6:20 pmLambert-St Louis
20h 41m
1 stop
PTY3:01 pmPanama City Tocumen Intl
Apr 8
PTY1:49 pmPanama City Tocumen Intl
8h 35m
1 stop
STL10:24 pmLambert-St Louis
$455
American Airlines
Apr 10
STL6:55 pmLambert-St Louis
17h 51m
2 stops
PTY12:46 pmPanama City Tocumen Intl
Apr 17
PTY1:49 pmPanama City Tocumen Intl
18h 41m
2 stops
STL8:30 amLambert-St Louis
$466
American Airlines
May 14
STL6:54 pmLambert-St Louis
17h 52m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 17
PTY1:49 pmPanama City Tocumen Intl
21h 20m
2 stops
STL11:09 amLambert-St Louis
$471

Copa Airlines flights from Missouri to Panama City

Our best Copa Airlines deals on Missouri to Panama City flight tickets
Copa Airlines
Aug 4
MCI3:16 pmKansas City
12h 48m
2 stops
PTY4:04 amPanama City Tocumen Intl
Aug 18
PTY3:30 pmPanama City Tocumen Intl
18h 51m
2 stops
MCI10:21 amKansas City
$433
Copa Airlines
Jul 23
MCI6:00 amKansas City
22h 04m
1 stop
PTY4:04 amPanama City Tocumen Intl
Jul 27
PTY3:30 pmPanama City Tocumen Intl
18h 33m
1 stop
MCI10:03 amKansas City
$438
Copa Airlines
Aug 4
MCI6:00 amKansas City
12h 37m
2 stops
PTY6:37 pmPanama City Tocumen Intl
Aug 18
PTY3:30 pmPanama City Tocumen Intl
18h 35m
1 stop
MCI10:05 amKansas City
$441

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 3, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 5/10

5:15 pm-4:12 pm

2 stops22h 57m

Panama City Tocumen Intl

Wed 5/20

7:55 am-4:42 pm

1 stop8h 47m

$431

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 8/4

3:16 pm-4:04 am

2 stops12h 48m

Panama City Tocumen Intl

Tue 8/18

3:30 pm-10:21 am

2 stops18h 51m

$433

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 5/10

2:59 pm-2:14 pm

1 stop23h 15m

Panama City Tocumen Intl

Wed 5/20

7:55 am-4:42 pm

1 stop8h 47m

$435

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 7/23

6:00 am-4:04 am

1 stop22h 04m

Panama City Tocumen Intl

Mon 7/27

3:30 pm-10:03 am

1 stop18h 33m

$438

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 8/2

8:30 am-2:14 pm

1 stop29h 44m

Panama City Tocumen Intl

Mon 8/10

3:30 pm-10:21 am

2 stops18h 51m

$439

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 8/4

6:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Tue 8/18

3:30 pm-10:05 am

1 stop18h 35m

$441

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/7

10:09 am-6:37 pm

1 stop8h 28m

Panama City Tocumen Intl

Thu 4/9

10:00 am-10:28 pm

1 stop12h 28m

$445

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/1

6:20 pm-3:01 pm

1 stop20h 41m

Panama City Tocumen Intl

Wed 4/8

1:49 pm-10:24 pm

1 stop8h 35m

$455

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:54 pm-12:46 pm

2 stops17h 52m

Panama City Tocumen Intl

Sun 5/17

1:49 pm-11:09 am

2 stops21h 20m

$471

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 4/25

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Sat 5/2

2:27 pm-11:36 pm

1 stop9h 09m

$479

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Missouri to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Missouri to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $437. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from Missouri to Panama City during November average around $510.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $566 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Missouri for as low as $416 on momondo.

Can stopping save me money on Missouri to Panama City flights?

You could potentially save up to 12% on your flight if you consider stops on a Missouri to Panama City flight.

Cheap Missouri to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City

Fastest flight time

7h 59m

Direct flights

None
The fastest flight from Missouri to Panama City takes 7h 59m
There are no direct flights from Missouri to Panama City. There are no popular flight routes from Missouri to Panama City.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama City Tocumen Intl Airport?

    Prices for flights from Missouri to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Missouri to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama City

Compare and see reviews for airlines that fly from Missouri to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $227Free CancellationRating
7.9
8,242 reviews
Search Delta flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,377 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,375 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Missouri.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama City?

Once all potential Missouri to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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