Cheap flights from Guayaquil to Panama City from $183

In general, May is the cheapest month to fly from Guayaquil to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. If you’re not able to fly to Panama City in May, then April is your next best option. Flight prices from Guayaquil to Panama City during April average around $309.

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $476. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $564. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Guayaquil to Panama City during this time can be as low as $414. Try not to purchase tickets at noon because they tend to be around $561. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl for the best Guayaquil Jose Joaquin de Olmedo - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guayaquil for as low as $305 on momondo.

There are 3 cabin classes available to choose from on Guayaquil to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 6% on your flight if you consider stops on a Guayaquil to Panama City flight.

As of November 2026, prices for Guayaquil to Panama City flights are approximately 27% more expensive when compared to flights at the same time last year.

Historically, on average around 3% of flights between Guayaquil and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 102 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 3% of their flights experiencing any sort of delay.

As of November 2026, there are 13 flights per day flying from Guayaquil to Panama City. The most common time of day flights depart is 2:00PM, with 45% of flights taking off in the afternoon.

As of November 2026, 96 flights take off from Guayaquil and land in Panama City each week. The most common flight departure day for this route is Wed, with 16% of weekly flights taking off on this day.