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Cheap flights from Guayaquil to Panama City from $147

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Panama City departing on 1/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Guayaquil to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
10:25 am - 4:55 pm
GYE
-
PTY
6h 30m1 stop
Avianca Logo
2:55 am - 9:15 am
PTY
-
GYE
6h 20m1 stop
$301Avianca
Mon, Feb 9 - Sat, Feb 14
Avianca Logo
6:55 pm - 8:50 am
GYE
-
PTY
13h 55m1 stop
Avianca Logo
2:55 am - 9:15 am
PTY
-
GYE
6h 20m1 stop
$303Avianca
Mon, Jan 19 - Wed, Jan 21
Avianca Logo
9:45 am - 4:30 pm
GYE
-
PTY
6h 45m1 stop
Avianca Logo
3:20 am - 11:20 am
PTY
-
GYE
8h 00m2 stops
$311Avianca
Mon, Apr 13 - Sun, Apr 19
Avianca Logo
9:05 am - 4:55 pm
GYE
-
PTY
7h 50m1 stop
Avianca Logo
2:55 am - 9:15 am
PTY
-
GYE
6h 20m1 stop
$313Avianca
Tue, Jan 6 - Fri, Jan 9
Avianca Logo
6:55 pm - 12:40 am
GYE
-
PTY
5h 45m1 stop
Avianca Logo
2:55 am - 11:25 am
PTY
-
GYE
8h 30m2 stops
$323Avianca
Mon, Jan 19 - Wed, Jan 21
Avianca Logo
10:25 am - 4:55 pm
GYE
-
PTY
6h 30m1 stop
Avianca Logo
9:45 am - 2:30 pm
PTY
-
GYE
4h 45m1 stop
$325Avianca
Fri, Feb 20 - Thu, Feb 26
Avianca Logo
3:30 am - 8:50 am
GYE
-
PTY
5h 20m1 stop
Avianca Logo
2:55 am - 9:15 am
PTY
-
GYE
6h 20m1 stop
$326Avianca
Wed, Feb 18 - Fri, Feb 27
Avianca Logo
3:30 am - 8:50 am
GYE
-
PTY
5h 20m1 stop
Avianca Logo
9:45 am - 2:30 pm
PTY
-
GYE
4h 45m1 stop
$327Avianca
Sun, Mar 15 - Thu, Mar 19
Copa Airlines Logo
6:33 pm - 8:41 pm
GYE
-
PTY
2h 08mnonstop
Copa Airlines Logo
11:17 am - 1:34 pm
PTY
-
GYE
2h 17mnonstop
$335Copa Airlines
Wed, Feb 4 - Sun, Feb 8
Avianca Logo
6:55 pm - 12:40 am
GYE
-
PTY
5h 45m1 stop
Avianca Logo
9:45 am - 2:25 pm
PTY
-
GYE
4h 40m1 stop
$339Avianca
Fri, Jan 9 - Mon, Jan 12

Avianca flights from Guayaquil to Panama City

Our best Avianca deals on Guayaquil to Panama City flight tickets
Avianca
Feb 9
GYE3:35 pmGuayaquil Jose Joaquin de Olmedo
9h 05m
1 stop
PTY12:40 amPanama City Tocumen Intl
Feb 14
PTY2:55 amPanama City Tocumen Intl
6h 20m
1 stop
GYE9:15 amGuayaquil Jose Joaquin de Olmedo
$301
Find similar
Avianca
Jan 19
GYE6:55 pmGuayaquil Jose Joaquin de Olmedo
13h 55m
1 stop
PTY8:50 amPanama City Tocumen Intl
Jan 21
PTY2:55 amPanama City Tocumen Intl
6h 20m
1 stop
GYE9:15 amGuayaquil Jose Joaquin de Olmedo
$303
Find similar
Avianca
Apr 13
GYE9:45 amGuayaquil Jose Joaquin de Olmedo
6h 45m
1 stop
PTY4:30 pmPanama City Tocumen Intl
Apr 19
PTY3:20 amPanama City Tocumen Intl
8h 00m
2 stops
GYE11:20 amGuayaquil Jose Joaquin de Olmedo
$311
Find similar

Copa Airlines flights from Guayaquil to Panama City

Our best Copa Airlines deals on Guayaquil to Panama City flight tickets
Copa Airlines
Feb 4
GYE6:33 pmGuayaquil Jose Joaquin de Olmedo
2h 08m
PTY8:41 pmPanama City Tocumen Intl
Feb 8
PTY11:17 amPanama City Tocumen Intl
2h 17m
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
$335
Find similar
Copa Airlines
Jan 9
GYE8:34 amGuayaquil Jose Joaquin de Olmedo
2h 07m
PTY10:41 amPanama City Tocumen Intl
Jan 14
PTY9:02 amPanama City Tocumen Intl
2h 16m
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
$347
Find similar
Copa Airlines
Jan 9
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
2h 08m
PTY2:28 pmPanama City Tocumen Intl
Jan 14
PTY9:02 amPanama City Tocumen Intl
2h 16m
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
$359
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Guayaquil to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 2/9

10:25 am-4:55 pm

1 stop6h 30m

Panama City Tocumen Intl

Sat 2/14

2:55 am-9:15 am

1 stop6h 20m

$301

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 1/19

6:55 pm-8:50 am

1 stop13h 55m

Panama City Tocumen Intl

Wed 1/21

2:55 am-9:15 am

1 stop6h 20m

$303

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 4/13

9:45 am-4:30 pm

1 stop6h 45m

Panama City Tocumen Intl

Sun 4/19

3:20 am-11:20 am

2 stops8h 00m

$311

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Tue 1/6

9:05 am-4:55 pm

1 stop7h 50m

Panama City Tocumen Intl

Fri 1/9

2:55 am-9:15 am

1 stop6h 20m

$313

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 1/19

6:55 pm-12:40 am

1 stop5h 45m

Panama City Tocumen Intl

Wed 1/21

2:55 am-11:25 am

2 stops8h 30m

$323

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

10:25 am-4:55 pm

1 stop6h 30m

Panama City Tocumen Intl

Thu 2/26

9:45 am-2:30 pm

1 stop4h 45m

$325

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

3:30 am-8:50 am

1 stop5h 20m

Panama City Tocumen Intl

Fri 2/27

2:55 am-9:15 am

1 stop6h 20m

$326

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

3:30 am-8:50 am

1 stop5h 20m

Panama City Tocumen Intl

Thu 3/19

9:45 am-2:30 pm

1 stop4h 45m

$327

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 2/4

6:33 pm-8:41 pm

Nonstop2h 08m

Panama City Tocumen Intl

Sun 2/8

11:17 am-1:34 pm

Nonstop2h 17m

$335

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Fri 1/9

6:55 pm-12:40 am

1 stop5h 45m

Panama City Tocumen Intl

Mon 1/12

9:45 am-2:25 pm

1 stop4h 40m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Guayaquil to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, May is the cheapest month to fly from Guayaquil to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $246. If you’re not able to fly to Panama City in May, then June is your next best option. Flight prices from Guayaquil to Panama City during June average around $246.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $449. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $538. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Guayaquil to Panama City during this time can be as low as $422. Try not to purchase tickets at noon because they tend to be around $567. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl flight route?

Fly from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl for the best Guayaquil Jose Joaquin de Olmedo - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $309 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guayaquil for as low as $254 on momondo.

What cabin class options are available on Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Guayaquil to Panama City flights?

No. A direct flight is the cheapest option for a flight between Guayaquil to Panama City.

How have Guayaquil to Panama City flight prices changed over time?

As of December 2025, prices for Guayaquil to Panama City flights are approximately 48% more expensive when compared to flights at the same time last year.

When to book flights from Guayaquil to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Panama City (GYE to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Panama City

Best Price Found

$238

Fastest flight time

2h 07m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Guayaquil in the past 72 hours is $238. The best round-trip flight deal from Guayaquil to Panama City found on momondo in the last 72 hours is $385.
The fastest flight from Guayaquil to Panama City takes 2h 07m
Direct flights go from Guayaquil to Panama City every day.
There is 1 airport in Panama City. From Guayaquil there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 772.2 mi away from Guayaquil Jose Joaquin de Olmedo. Typically, this will take 2h 07m by plane in normal conditions.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Guayaquil Jose Joaquin de Olmedo Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Guayaquil to Panama City?

  • What is the most popular airline from Guayaquil to Panama City?

Best airlines flying from Guayaquil to Panama City

Compare and see reviews for airlines that fly from Guayaquil to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $222Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
AviancaPriceFrom $236Free CancellationRating
6.6
2,492 reviews
Search Avianca flights

  • Copa Airlines Flights From Guayaquil to Panama City

    Copa Airlines flies from Guayaquil to Panama City around 33 times per week, with 1,557 momondo users rating the airline 7.6/10. The cheapest Copa Airlines deal from Guayaquil to Panama City in the last 72 hours was $222 (round-trip), much lower than the average airfare cost of $383 for Copa Airlines flights on this route.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Guayaquil to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Guayaquil to Panama City with flexible booking policies on momondo?

All flight searches from Guayaquil to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Guayaquil to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Guayaquil. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Guayaquil to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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