Cheap flights from Guatemala City to Panama City from $155

In general, November is the cheapest month to fly from Guatemala City to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $279. If you’re not able to fly to Panama City in November, then October is your next best option. Flight prices from Guatemala City to Panama City during October average around $281.

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $403. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $516. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Guatemala City to Panama City during this time can be as low as $371. Try not to purchase tickets at noon because they tend to be around $1,035. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Guatemala City La Aurora to Panama City Tocumen Intl for the best Guatemala City La Aurora - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Guatemala City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $307 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guatemala City for as low as $283 on momondo.

There are 3 cabin classes available to choose from on Guatemala City to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 7% on your flight if you consider stops on a Guatemala City to Panama City flight.

As of September 2026, prices for Guatemala City to Panama City flights are approximately 9% cheaper when compared to flights at the same time last year.

Historically, on average around 3% of flights between Guatemala City and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 3% of their flights experiencing any sort of delay.

San José (SJO) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via San José (SJO) offer the lowest average round-trip price of $268.

Flights connecting via San Salvador (SAL) have the shortest average one-way travel time: 4h 20m.

San José (SJO) has the shortest average layover time for this route: 1h 49m.

As of September 2026, 18 flights take off from Guatemala City and land in Panama City each day. The most common flight departure time for this route is 12:00PM, with 55% of daily flights taking off in the afternoon.

As of September 2026, 129 flights take off from Guatemala City and land in Panama City each week. The most common flight departure day for this route is Wed, with 15% of weekly flights taking off on this day.