Cheap flights from Cali to Panama City from $160

In general, May is the cheapest month to fly from Cali to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $201. If you’re not able to fly to Panama City in May, then November is your next best option. Flight prices from Cali to Panama City during November average around $202.

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $423. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $469. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Cali to Panama City during this time can be as low as $434. Try not to purchase tickets in the afternoon because they tend to be around $487. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Cali Alfonso B. Aragon Intl to Panama City Tocumen Intl for the best Cali Alfonso B. Aragon Intl - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Cali when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $233 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Cali for as low as $187 on momondo.

You could potentially save up to 30% on your flight if you consider stops on a Cali to Panama City flight.

As of May 2026, prices for Cali to Panama City flights are approximately 9% more expensive when compared to flights at the same time last year.

Avianca and Copa Airlines are the most popular carriers operating from Cali Alfonso B. Aragon Intl to Panama City Tocumen Intl

Copa Airlines, Wingo and Avianca are the top three most popular airlines that fly to Panama City from Cali according to our data. Copa Airlines is the first choice among our users, with 64% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 2% of flights between Cali and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 93 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 2% of their flights experiencing any sort of delay.

As of May 2026, 9 flights take off from Cali and land in Panama City each day. The most common flight departure time for this route is 3:00PM, with 64% of daily flights taking off in the afternoon.

The number of flights available between Cali and Panama City is 66 per week as of May 2026. The most frequent departure day is Mon, with 18% of weekly flights leaving on this day.