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Cheap flights from Mississippi to Panama City from $240

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Panama City departing on 12/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Mississippi to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:40 am - 2:45 pmMEM-PTY
7h 05m1 stop
United Airlines Logo
4:41 pm - 9:13 amPTY-MEM
17h 32m1 stop
$490United Airlines
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Wed, Dec 10 - Wed, Jan 14
American Airlines Logo
3:44 pm - 1:47 pmMEM-PTY
21h 03m2 stops
American Airlines Logo
2:30 pm - 8:35 amPTY-MEM
19h 05m2 stops
$494American Airlines
Find Deal
Wed, Dec 10 - Fri, Feb 13
United Airlines Logo
5:11 pm - 2:45 pmGPT-PTY
20h 34m1 stop
United Airlines Logo
8:55 am - 4:03 pmPTY-GPT
8h 08m1 stop
$495United Airlines
Find Deal
Wed, Dec 10 - Sun, Dec 21
American Airlines Logo
6:13 pm - 3:42 pmGPT-PTY
20h 29m2 stops
American Airlines Logo
2:53 pm - 12:16 pmPTY-GPT
22h 23m2 stops
$497American Airlines
Find Deal
Wed, Dec 10 - Sun, Dec 21
American Airlines Logo
6:29 pm - 1:27 pmMEM-PTY
17h 58m1 stop
American Airlines Logo
2:30 pm - 11:14 pmPTY-MEM
9h 44m1 stop
$500American Airlines
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Mon, Feb 9 - Fri, Feb 13
Delta Logo
5:40 am - 2:21 pmJAN-PTY
7h 41m1 stop
Delta Logo
8:05 am - 5:21 pmPTY-JAN
10h 16m1 stop
$508Delta
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Sat, Dec 6 - Sat, Dec 13
Multiple Airlines Logo
7:00 am - 12:45 amMEM-PTY
17h 45m2 stops
Multiple Airlines Logo
5:50 pm - 11:08 pmPTY-MEM
29h 18m2 stops
$573Multiple Airlines
Find Deal
Wed, Oct 22 - Sun, Oct 26
Multiple Airlines Logo
6:17 pm - 2:00 pmMEM-PTY
18h 43m3 stops
Multiple Airlines Logo
5:55 pm - 6:15 pmPTY-MEM
25h 20m2 stops
$577Multiple Airlines
Find Deal
Sat, Feb 7 - Sat, Feb 21
Delta Logo
5:59 pm - 8:00 pmMOB-PTY
25h 01m1 stop
Delta Logo
8:00 am - 8:34 amPTY-MOB
25h 34m1 stop
$980Delta
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Mon, Dec 22 - Sat, Dec 27
WestJet Logo
5:59 pm - 9:20 amMOB-PTY
38h 21m2 stops
WestJet Logo
10:20 am - 11:20 pmPTY-MOB
38h 00m2 stops
$5,097WestJet
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Tue, Dec 23 - Sun, Dec 28

American Airlines flights from Mississippi to Panama City

Our best American Airlines deals on Mississippi to Panama City flight tickets
American Airlines
Dec 10
MEM3:44 pmMemphis
21h 03m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Feb 13
PTY2:30 pmPanama City Tocumen Intl
19h 05m
2 stops
MEM8:35 amMemphis
$494
Find similar
American Airlines
Dec 10
GPT6:13 pmGulfport Biloxi Regional
20h 29m
2 stops
PTY3:42 pmPanama City Tocumen Intl
Dec 21
PTY2:53 pmPanama City Tocumen Intl
22h 23m
2 stops
GPT12:16 pmGulfport Biloxi Regional
$497
Find similar
American Airlines
Feb 9
MEM6:29 pmMemphis
17h 58m
1 stop
PTY1:27 pmPanama City Tocumen Intl
Feb 13
PTY2:30 pmPanama City Tocumen Intl
9h 44m
1 stop
MEM11:14 pmMemphis
$500
Find similar

United Airlines flights from Mississippi to Panama City

Our best United Airlines deals on Mississippi to Panama City flight tickets
United Airlines
Dec 10
MEM6:40 amMemphis
7h 05m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Jan 14
PTY4:41 pmPanama City Tocumen Intl
17h 32m
1 stop
MEM9:13 amMemphis
$490
Find similar
United Airlines
Dec 10
GPT5:11 pmGulfport Biloxi Regional
20h 34m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Dec 21
PTY8:55 amPanama City Tocumen Intl
8h 08m
1 stop
GPT4:03 pmGulfport Biloxi Regional
$495
Find similar
United Airlines
Apr 6
GPT5:15 pmGulfport Biloxi Regional
20h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Apr 12
PTY7:55 amPanama City Tocumen Intl
11h 47m
1 stop
GPT7:42 pmGulfport Biloxi Regional
$535
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 9, 2025.
Use the filters below to find and compare flights from Mississippi to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Wed 12/10

6:40 am-2:45 pm

1 stop7h 05m

Panama City Tocumen Intl

Wed 1/14

4:41 pm-9:13 am

1 stop17h 32m

$490

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Wed 12/10

3:44 pm-1:47 pm

2 stops21h 03m

Panama City Tocumen Intl

Fri 2/13

2:30 pm-8:35 am

2 stops19h 05m

$494

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Wed 12/10

5:11 pm-2:45 pm

1 stop20h 34m

Panama City Tocumen Intl

Sun 12/21

8:55 am-4:03 pm

1 stop8h 08m

$495

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Wed 12/10

6:13 pm-3:42 pm

2 stops20h 29m

Panama City Tocumen Intl

Sun 12/21

2:53 pm-12:16 pm

2 stops22h 23m

$497

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Mon 2/9

6:29 pm-1:27 pm

1 stop17h 58m

Panama City Tocumen Intl

Fri 2/13

2:30 pm-11:14 pm

1 stop9h 44m

$500

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Sat 12/6

5:40 am-2:21 pm

1 stop7h 41m

Panama City Tocumen Intl

Sat 12/13

8:05 am-5:21 pm

1 stop10h 16m

$508

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Wed 10/22

7:00 am-12:45 am

2 stops17h 45m

Panama City Tocumen Intl

Sun 10/26

5:50 pm-11:08 pm

2 stops29h 18m

$573

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Sat 2/7

6:17 pm-2:00 pm

3 stops18h 43m

Panama City Tocumen Intl

Sat 2/21

5:55 pm-6:15 pm

2 stops25h 20m

$577

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Mon 12/22

5:59 pm-8:00 pm

1 stop25h 01m

Panama City Tocumen Intl

Sat 12/27

8:00 am-8:34 am

1 stop25h 34m

$980

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Tue 12/23

5:59 pm-9:20 am

2 stops38h 21m

Panama City Tocumen Intl

Sun 12/28

10:20 am-11:20 pm

2 stops38h 00m

$5,097

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Mississippi to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Saturday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $417. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $1,055. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Cheap Mississippi to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Panama City

Direct flights

None
There are no direct flights from Mississippi to Panama City. There are no popular flight routes from Mississippi to Panama City.
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  • When did momondo last update prices for flights from Mississippi to Panama City Tocumen Intl Airport?

    Prices for flights from Mississippi to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Mississippi to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Mississippi to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Panama City

Compare and see reviews for airlines that fly from Mississippi to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $445Free CancellationRating
7.4
8,968 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Panama City?

Finding the right flight to Panama City from Mississippi is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Mississippi to Panama City with flexible booking policies on momondo?

Yes. All flights to Panama City from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Mississippi. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mississippi to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Mississippi. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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