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Cheap flights from Buffalo to Panama City from $517

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Buffalo to Panama City (BUF-PTY)

Cheap round-trip flights

Delta Logo
6:00 am - 12:55 pmBUF-PTY
7h 55m1 stop
Delta Logo
2:21 pm - 11:39 pmPTY-BUF
8h 18m1 stop
$517Delta
Find Deal
Sat, Oct 4 - Sat, Oct 11
Delta Logo
3:52 pm - 12:55 pmBUF-PTY
22h 03m2 stops
Delta Logo
2:21 pm - 8:23 amPTY-BUF
17h 02m2 stops
$522Delta
Find Deal
Sat, Oct 4 - Wed, Oct 15
Delta Logo
4:43 pm - 12:55 pmBUF-PTY
21h 12m1 stop
Delta Logo
2:21 pm - 11:39 pmPTY-BUF
8h 18m1 stop
$527Delta
Find Deal
Fri, Oct 3 - Sat, Oct 11
Delta Logo
4:43 pm - 12:55 pmBUF-PTY
21h 12m1 stop
Delta Logo
2:21 pm - 9:50 amPTY-BUF
18h 29m2 stops
$531Delta
Find Deal
Fri, Oct 3 - Fri, Oct 10
Delta Logo
6:00 am - 12:56 pmBUF-PTY
7h 56m1 stop
Delta Logo
2:21 pm - 11:39 pmPTY-BUF
8h 18m1 stop
$544Delta
Find Deal
Wed, Oct 8 - Fri, Oct 10
United Airlines Logo
11:24 am - 8:02 pmBUF-PTY
8h 38m1 stop
United Airlines Logo
11:55 pm - 8:41 pmPTY-BUF
20h 46m2 stops
$568United Airlines
Find Deal
Sat, Jan 17 - Fri, Jan 23
American Airlines Logo
5:25 pm - 2:31 pmBUF-PTY
22h 06m2 stops
American Airlines Logo
3:15 pm - 11:10 amPTY-BUF
18h 55m2 stops
$637American Airlines
Find Deal
Fri, Oct 3 - Sun, Oct 12
American Airlines Logo
6:00 am - 2:31 pmBUF-PTY
9h 31m2 stops
American Airlines Logo
3:15 pm - 11:43 pmPTY-BUF
31h 28m2 stops
$652American Airlines
Find Deal
Fri, Oct 3 - Mon, Oct 13
Logo
6:59 pm - 5:16 pmBUF-PTY
23h 17m2 stops
Logo
9:25 am - 11:19 amPTY-BUF
24h 54m1 stop
$775
Find Deal
Fri, Oct 3 - Sat, Oct 11
Logo
8:19 pm - 8:37 pmBUF-PTY
25h 18m2 stops
Logo
9:06 am - 7:34 pmPTY-BUF
9h 28m1 stop
$786
Find Deal
Thu, Oct 9 - Thu, Oct 16

Delta flights from Buffalo to Panama City

Our best Delta deals on Buffalo to Panama City flight tickets
Delta
Oct 4
BUF6:00 amBuffalo
7h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Oct 11
PTY2:21 pmPanama City Tocumen Intl
8h 18m
1 stop
BUF11:39 pmBuffalo
$517
Find similar
Delta
Oct 4
BUF3:52 pmBuffalo
22h 03m
2 stops
PTY12:55 pmPanama City Tocumen Intl
Oct 15
PTY2:21 pmPanama City Tocumen Intl
17h 02m
2 stops
BUF8:23 amBuffalo
$522
Find similar
Delta
Oct 3
BUF4:43 pmBuffalo
21h 12m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Oct 11
PTY2:21 pmPanama City Tocumen Intl
8h 18m
1 stop
BUF11:39 pmBuffalo
$527
Find similar

American Airlines flights from Buffalo to Panama City

Our best American Airlines deals on Buffalo to Panama City flight tickets
American Airlines
Oct 3
BUF5:25 pmBuffalo
22h 06m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Oct 12
PTY3:15 pmPanama City Tocumen Intl
18h 55m
2 stops
BUF11:10 amBuffalo
$637
Find similar
American Airlines
Oct 3
BUF6:00 amBuffalo
9h 31m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Oct 13
PTY3:15 pmPanama City Tocumen Intl
31h 28m
2 stops
BUF11:43 pmBuffalo
$652
Find similar
American Airlines
Oct 8
BUF6:07 amBuffalo
32h 56m
2 stops
PTY2:03 pmPanama City Tocumen Intl
Oct 13
PTY3:15 pmPanama City Tocumen Intl
23h 20m
2 stops
BUF3:35 pmBuffalo
$672
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 8, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 10/4

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Sat 10/11

2:21 pm-11:39 pm

1 stop8h 18m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 10/4

3:52 pm-12:55 pm

2 stops22h 03m

Panama City Tocumen Intl

Wed 10/15

2:21 pm-8:23 am

2 stops17h 02m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 10/3

4:43 pm-12:55 pm

1 stop21h 12m

Panama City Tocumen Intl

Sat 10/11

2:21 pm-11:39 pm

1 stop8h 18m

$527

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 10/3

4:43 pm-12:55 pm

1 stop21h 12m

Panama City Tocumen Intl

Fri 10/10

2:21 pm-9:50 am

2 stops18h 29m

$531

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 10/8

6:00 am-12:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Fri 10/10

2:21 pm-11:39 pm

1 stop8h 18m

$544

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/17

11:24 am-8:02 pm

1 stop8h 38m

Panama City Tocumen Intl

Fri 1/23

11:55 pm-8:41 pm

2 stops20h 46m

$568

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 10/3

5:25 pm-2:31 pm

2 stops22h 06m

Panama City Tocumen Intl

Sun 10/12

3:15 pm-11:10 am

2 stops18h 55m

$637

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 10/3

6:00 am-2:31 pm

2 stops9h 31m

Panama City Tocumen Intl

Mon 10/13

3:15 pm-11:43 pm

2 stops31h 28m

$652

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 10/3

6:59 pm-5:16 pm

2 stops23h 17m

Panama City Tocumen Intl

Sat 10/11

9:25 am-11:19 am

1 stop24h 54m

$775

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/9

8:19 pm-8:37 pm

2 stops25h 18m

Panama City Tocumen Intl

Thu 10/16

9:06 am-7:34 pm

1 stop9h 28m

$786

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $480. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $760. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Buffalo to Panama City during this time can be as low as $386. Try not to purchase tickets in the morning because they tend to be around $628. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Buffalo to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City (BUF to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City

Direct flights

None
There are no direct flights from Buffalo to Panama City. There are no popular flight routes from Buffalo to Panama City.
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  • How far is Buffalo to Panama City Tocumen Intl by plane?

    Buffalo and Panama City Tocumen Intl are 2341.1 mi apart from one another. Flights usually cover this in 7h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Buffalo Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Panama City?

Best airlines flying from Buffalo to Panama City

Compare and see reviews for airlines that fly from Buffalo to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $441Free CancellationRating
7.4
8,940 reviews
Search United Airlines flights
DeltaPriceFrom $445Free CancellationRating
7.9
7,972 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

Finding the right flight to Panama City from Buffalo is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

Flights from Buffalo to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Buffalo.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Buffalo. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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