- AC Hotel by Marriott Des Moines East Village
- Adventureland Inn
- AmericInn by Wyndham Des Moines Airport
- Baymont by Wyndham Des Moines Airport
- Baymont by Wyndham Des Moines North
- Budget Inn & Suites
- Clarion Inn Des Moines Airport
- Comfort Inn & Suites Event Center
- Cozy Rest Motel
- Days Inn & Suites by Wyndham Des Moines Airport
- Des Lux Hotel
- Des Moines Marriott Downtown
- Econo Lodge Inn & Suites Fairgrounds
- Embassy Suites Hotel Des Moines Downtown
- Fairfield Inn & Suites By Marriott Des Moines Downtown
- Fairfield Inn & Suites by Marriott Des Moines Airport
- Hampton Inn & Suites Des Moines Downtown
- Hampton Inn Des Moines-Airport
- Hilton Des Moines Downtown
- Hilton Garden Inn Des Moines Airport
- Historical Oscar Lofquist house in the heart of Des Moines
- Holiday Inn Des Moines Dtwn - Mercy Area
- Holiday Inn Des Moines-Airport/Conf Center
- Holiday Inn Express & Suites Des Moines Downtown
- Holiday Inn Hotel & Suites Des Moines-Northwest, An IHG Hotel
- Home2 Suites by Hilton Des Moines at Drake University
- Homewood Suites by Hilton - Des Moines Airport
- Hotel Fort Des Moines, Curio Collection By Hilton
- Hyatt Place Des Moines Downtown
- Motel 6 Des Moines Ia
- Palace Inn
- Quality Inn
- Quality Inn & Suites Des Moines Airport
- Quality Inn and Suites Des Moines - Merle Hay Road
- Ramada by Wyndham Des Moines Tropics Resort & Conference Ctr
- Red Roof Inn Des Moines
- Renaissance Des Moines Savery Hotel
- Residence Inn by Marriott Des Moines Downtown
- Sonesta Essential Des Moines
- Staybridge Suites Des Moines Downtown
- Super 8 by Wyndham Clive IA
- Super 8 by Wyndham Des Moines
- Surety Hotel